162062-52-4Relevant academic research and scientific papers
Regioselective functionalization of unprotected myo-inositol by electrophilic substitution
Watanabe, Yutaka,Uemura, Tsuyoshi,Yamauchi, Satoe,Tomita, Kousei,Saeki, Takafumi,Ishida, Ryousuke,Hayashi, Minoru
, p. 4657 - 4664 (2013/06/26)
Unprotected myo-inositol was treated with various electrophiles, such as aroyl chlorides, tosyl chloride and tert-butyldiphenylsilyl chloride in a solution of LiCl/DMA or DMSO to afford regioselectively 1,3-di-O-substituted or racemic 1-O-substituted deri
One-step regioselective functionalization of myo-inositol by dissolution strategy
Yamauchi, Satoe,Hayashi, Minoru,Watanabe, Yutaka
experimental part, p. 2287 - 2290 (2009/12/06)
Functionalizations of hydroxy groups of myo-inositol were usually nonselective due to its poor solubility. By dissolving myo-inositol in DMSO or LiCl-N,N-dimethylacetamide, we have achieved regioselective acylation, silylation, sulfonylation, phosphinylat
Syntheses of myo-inositol-1,2,3,5- and 2,4,5,6-tetrakisphosphates, unusual inhibitors of myo-inositol-1,4,5-trisphosphae 3-kinase
Chung, Sung-Kee,Chang, Young-Tae
, p. 2715 - 2718 (2007/10/03)
D-myo-Inositol 1,4,5-trisphosphate [D-I(1,4,5)P3], a calcium mobilizing second messenger, is converted to D-I(1,3,4,5)P4 by D-I(1,4,5)P3-3-kinase. Efficient syntheses of I(1,2,3,5)P4 (2) and I(2,4,5,6)P4 (3), novel 3-kinase inhibitors, are reported.
Synthesis of All Possible Regioisomers of myo-Inositol Tetrakisphosphates
Chung, Sung-Kee,Chang, Young-Tae
, p. 11 - 12 (2007/10/02)
Synthesis of all possible nine regioisomers of IP4, some of which are implicated as second messengers in the cellular signalling, was accomplished from myo-inositol via its dibenzoate derivatives (IBz2) as the key intermediates; base-catalysed isomerization of readily available I(1,4)Bz2 and its derivatives, followed by suitable separation procedures efficiently provided all nine regioisomers of IBz2.
Base-catalysed Acyl Migrations in myo-Inositol Dibenzoates
Chung, Sung-Kee,Chang, Young-Tae
, p. 13 - 14 (2007/10/02)
Base-catalysed isomerizations of readily available I(1,4)Bz2 and its derivatives efficiently provided all nine regioisomers of IBz2 and the kinetic behaviour of the benzoyl-migration has been studied.
