1620680-34-3Relevant academic research and scientific papers
Total Synthesis of the Bacterial Diisonitrile Chalkophore SF2768
Xu, Yao,Tan, Derek S.
, p. 8731 - 8735 (2019)
Chalkophores are bacterial natural products that chelate and transport extracellular copper. The diisonitrile natural product SF2768 was first isolated from a Streptomyces species as an antifungal antibiotic and has more recently been characterized as a bacterial chalkophore and potential virulence factor. Herein, we report a modular synthesis of SF2768 and related acyclic analogues, allowing assignment of syn-stereochemistry across the central lactol ring. The copper-binding properties of these diisonitriles have also been studied.
BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2
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Page/Page column 18-19, (2014/08/07)
The present invention relates to novel pyrimido[1,6-a]pyrimidin-6(2H)-one compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
