1620697-50-8Relevant academic research and scientific papers
Enantioselective NiH/Pmrox-Catalyzed 1,2-Reduction of α,β-Unsaturated Ketones
Chen, Fenglin,Zhang, Yao,Yu, Lei,Zhu, Shaolin
, p. 2022 - 2025 (2017)
The enantioselective 1,2-reduction of α,β-unsaturated ketones was achieved using a NiH catalyst in the presence of pinacolborane. This mild process represents a general method to access a wide variety of structurally diverse α-chiral allylic alcohols in excellent yields and enantioselectivity, as well as very high levels of ambidoselectivity for 1,2- over 1,4-reduction. Furthermore, for reactions on a 10 mmol scale, catalyst loadings as low as 0.5 mol % could be employed to deliver product without any detrimental effect on the yield, enantio-, or ambidoselectivity.
Highly enantioselective hydrogenation of steric hindrance enones catalyzed by Ru complexes with chiral diamine and achiral phosphane
Chen, Xiangning,Zhou, Han,Zhang, Kunyu,Li, Jiawen,Huang, Hanmin
, p. 3912 - 3915 (2014/08/18)
An asymmetric hydrogenation of sterically hindered β,β- disubstituted enones has been well-established by using a ruthenium complex composed of an achiral diphosphane and a chiral diamine as catalyst, wherein the carbonyl group was selectively hydrogenated to give a wide range of chiral allylic alcohols with high levels of enantioselectivity and complete chemoselectivity.
