1620740-65-9

Usage

Chemical structure

A chemical compound derived from piperidine and 4-methylbenzenesulfonyl chloride.

Functional groups

Contains an acryloyl group and a sulfonate group.

Polymerization suitability

The acryloyl group makes it suitable for polymerization reactions.

Application in organic synthesis

Commonly used as a reagent in organic synthesis.

Modification of biomolecules

Particularly used in the modification of biomolecules.

Introduction of piperidin-4-yl motif

Can be used to introduce the piperidin-4-yl motif into various organic compounds.

Leaving group in nucleophilic substitution

The sulfonate group can act as a leaving group in nucleophilic substitution reactions.

Versatility

A versatile compound with useful applications in organic chemistry and bioconjugation.

Upstream product

• 814-68-6 acryloyl chloride 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 1620740-64-8 piperidin-4-yl 4-methylbenzenesulfonate hydrochloride 

Downstream Products

• 1092364-38-9 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one 

Relevant academic research and scientific papers

HETEROCYCLIC INHIBITORS OF TYROSINE KINASE

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of HER2 or EGFR for the treatment or prevention of disease, including cancer.

METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)PROP-2-EN-1-ONE

The present invention relates to a method for manufacturing a targeted 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a much simple way compared to an existing method by conducting a reaction of a compound of chemical formula 2 and a compound of chemical formula 3, among polar aprotic solvents in the presence of a base.COPYRIGHT KIPO 2019

METHOD FOR PREPARING 1-(4-(4-(3,4-DICHLORO-2-FLUOROPHENYLAMINO)-7-METHOXYQUINAZOLIN-6-YLOXY)PIPERIDIN-1-YL)PROP-2-EN-1-ONE

The present invention relates to a novel method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a simpler process as compared with conventional methods by allowing 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol to react with an N-acyl piperidine derivative in an inert polar protic solvent in the presence of a base.