1620843-80-2

Basic information

• Product Name: 5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-5,6,7,8-tetrahydroquinazolin-2-yl]amino]-2-methyl-benzenesulfonamide
• CAS NO: 1620843-80-2
• Molecular Weight: 491.617
• Mol File: 1620843-80-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-5,6,7,8-tetrahydroquinazolin-2-yl]amino]-2-methyl-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-5,6,7,8-tetrahydroquinazolin-2-yl]amino]-2-methyl-benzenesulfonamide(1620843-80-2)
• EPA Substance Registry System: 5-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-5,6,7,8-tetrahydroquinazolin-2-yl]amino]-2-methyl-benzenesulfonamide(1620843-80-2)

Safety Data

• Hazardous Substances Data: 1620843-80-2(Hazardous Substances Data)

Upstream product

• 6973-09-7 5-amino-2-methylbenzenesulfonamide 
• 1620059-36-0 C₁₈H₂₀ClN₅ 
• 1620059-33-7 C₁₇H₁₈ClN₅ 
• 444731-72-0 2,3-dimethyl-6-amino-2H-indazole 
• 444731-73-1 2,3?dimethyl?6?nitro?2H?indazole 
• 6494-19-5 3-methyl-6-nitro-1H-indazole 
• 20191-74-6 2-ethyl-5-nitroaniline 
• 578-54-1 ortho-ethylaniline 
• 1127-85-1 2,4-dichloro-5,6,7,8-tetrahydro-quinazoline 
• 35042-48-9 2,4-Dihydroxy-5,6,7,8-tetrahydroquinazoline 
• 41302-34-5 2-(methoxycarbonyl)cyclohexanone 

Relevant articles and documents

Discovery and synthesis of N2,N4-substitued- cycloalkyl[d]pyrimidine-2,4-diamine analogs: The first examples of small-molecular FGFR-1 activator

A series of novel, cycloalkyl-modified pazopanib analogs 2 and 3 were designed and synthesized. Their kinase modulatory effects on FGFR-1, VEGFR-2, PDGFR-β, and c-KIT were evaluated by the caliper mobility shift assay. Introduction of cycloalkyl into the pyrimidine linker of pazopanib almost abolished the four kinases inhibitory potency of compounds 2 and 3, but surprisingly, resulted in good activation effects on FGFR-1. Compounds 3d and 3g showed double-digit, nanomolar, selective activation effects on FGFR-1, and could be classified as first-generation small molecular activators of FGFR-1 kinase.