6973-09-7Relevant articles and documents
TGF-beta receptor inhibitor
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Paragraph 0142-0143; 0145; 0147-0149, (2021/04/28)
The invention provides a compound shown as a formula (I) and a pharmaceutical composition thereof. The compound shown as the formula (I) of the present invention is useful as a TGF-beta receptor inhibitor, particularly a TGF beta RI inhibitor, for example, in the prevention or treatment of various TGF beta RI (ALK5) mediated related diseases.
Preparation method of 2-methyl-5-aminobenzenesulfonamide
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Paragraph 0052; 0066; 0070, (2018/04/15)
The invention relates to a preparation method of 2-methyl-5-aminobenzenesulfonamide. The preparation method includes following steps: S1, allowing sulfonation: dissovling p-nitrotoluene and chlorosulfonic acid in an organic solvent I, stirring for reaction, and performing aftertreatment to obtain 2-methyl-5-nitrobenzene sulfonyl chloride; S2, allowing hydrogenation and addition: adding 2-methyl-5-nitrobenzene sulfonyl chloride obtained in the S1 into a hydrogenation kettle, sequentially adding a catalyst, ammonia water and an organic solvent II, allowing reaction at high temperature and high pressure, treating after reaction to obtain 2-methyl-5-aminobenzenesulfonamide which is light yellow solid. The preparation method has the advantages of short route, high product purify and easiness for industrial production.
N,N'-bis-substituted aryl thiourea derivatives and synthetic method and application thereof
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Paragraph 0069; 0074; 0075, (2017/04/26)
The invention discloses N,N'-bis-substituted aryl thiourea derivatives which are a series of compounds simultaneously containing various substituted aromatic ring structures and asymmetric substituted thiourea structures and are all novel structural compounds which are not reported in the literature. The biological activity test analysis of all the target compounds includes determination of DPPH antioxidant activity and antiviral activity. Results indicate that, in general, the designed and synthesized compounds are novel in structures and have the antioxidant activity and the antiviral activity revealed for the first time. In addition, the unknown biological activity is not fully elucidated, and thus the compounds are expected to provide a certain material basis for further research and development of new drugs.