1620846-16-3

Upstream product

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• 14432-12-3 4-Amino-2-chloropyridine 
• 320-94-5 2-nitro-4-trifluoromethylbenzoic acid 
• 115029-24-8 2-fluoro-4-(trifluoromethyl)benzoic acid 
• 126917-10-0 2-fluoro-4-(trifluoromethyl)benzoyl chloride 
• 1620847-67-7 2-fluoro-N-(2-methoxypyridin-4-yl)-4-(trifluoromethyl)benzamide 
• 20265-39-8 4-amino-2-methoxypyridine 

Relevant academic research and scientific papers

PROCESS FOR MAKING PYRIDONE AMIDES AND PRODRUGS THEREOF USEFUL AS MODULATORS OF SODIUM CHANNELS

The present application is directed to a process of preparing compounds of formula I, and intermediates thereof as well as pharmaceutically acceptable salts, wherein R2, R3, R5, R7 and X are defined herein. The

PRODRUGS OF PYRIDONE AMIDES USEFUL AS MODULATORS OF SODIUM CHANNELS

The invention relates to prodrug compounds of formula I: wherein R2, R3, R5, R7 and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS

The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.