162095-92-3

Upstream product

• 106773-36-8 4-methoxybenzyl-7-amino-3-chloromethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 134866-27-6 3-chloromethyl-7β-tert-butylcarbonylamino-3-cephem-4-carboxylic acid p-methoxybenzyl ester 

Downstream Products

• 1026059-78-8 p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E)-4-(imidazo[1,2-b]pyridazine-6-yl)-1-butenyl]-3-cephem-4-carboxylate 
• 185911-03-9 p-methoxybenzyl 7β-t-butoxycarbonylamino-3-[(E,Z)-2-(imidazo[1,2-b]pyridazine-6-yl)vinyl]-3-cephem-4-carboxylates 
• 651059-40-4 3-{3-(4-acetylamino-4-tert-butoxycarbonyl-butyrylamino)-3-[1-(1-tert-butoxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-propyl}-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 651059-41-5 (6R,7R)-3-{(S)-3-((R)-4-Acetylamino-4-tert-butoxycarbonyl-butyrylamino)-3-[(R)-1-((R)-1-tert-butoxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-propyl}-7-amino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 651059-37-9 (6R,7R)-3-[(S)-3-((R)-4-Acetylamino-4-tert-butoxycarbonyl-butyrylamino)-4-hydroxy-butyl]-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 651059-36-8 (6R,7R)-3-[(E)-(S)-3-((R)-4-Acetylamino-4-tert-butoxycarbonyl-butyrylamino)-4-hydroxy-but-1-enyl]-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 651059-33-5 (6R,7R)-7-tert-Butoxycarbonylamino-3-{(E)-2-[(S)-2,2-dimethyl-3-(4-nitro-benzyloxycarbonyl)-oxazolidin-4-yl]-vinyl}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 651059-34-6 (6R,7R)-3-((E)-(S)-3-Amino-4-hydroxy-but-1-enyl)-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 

Relevant academic research and scientific papers

A Mechanism-Based Inhibitor Targeting the DD-Transpeptidase Activity of Bacterial Penicillin-Binding Proteins

Penicillin-binding proteins (PBPs) are responsible for the final stages of bacterial cell wall assembly. These enzymes are targets of β-lactam antibiotics. Two of the PBP activities include DD-transpeptidase and DD-carboxypeptidase activities, which carry

Studies on anti-MRSA parenteral cephalosporins. III. Synthesis and antibacterial activity of 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)- alkoxyimininoacetamido]-3-[(E)-2-(1-alkylimidazol{1,2-b]pyridazinium-6-y) thiovinyl]-3-cephem-4-carboxylates and relat

In the course of our exploration for a novel cephalosporin derivative having excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), we modified the C-3 linked spacers of cephem derivatives bearing a 1-methylimidazo[1,