1621064-60-5

Basic information

• Product Name: 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate
• Synonyms: 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate
• CAS NO: 1621064-60-5
• Molecular Weight: 497.555
• Mol File: 1621064-60-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate(1621064-60-5)
• EPA Substance Registry System: 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate(1621064-60-5)

Safety Data

• Hazardous Substances Data: 1621064-60-5(Hazardous Substances Data)

Upstream product

• 26207-06-7 4-methylnaphthalen-2-ol 
• 937-05-3 cis-4-tert-butyl-1-cyclohexanol 
• 1266120-06-2 1-methyl-3-{[trans-4-tert-butylcyclohexyl]methyl}naphthalene 
• 18508-91-3 methanesulfonic acid 4-tert-butylcyclohexyl ester 
• 1621064-61-6 2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methyl-1-naphthaldehyde 
• 1621064-62-7 methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate 
• 1621064-59-2 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid 
• 76-05-1 trifluoroacetic acid 
• 79325-54-5 2-Hydroxy-4-methyl-1-naphthaldehyde 
• 57404-87-2 3-methoxy-1-methylnaphthalene 

Relevant articles and documents

Novel Potent Selective Orally Active S1P5 Receptor Antagonists

S1P5 is one of the five sphingosine-1-phosphate (S1P) receptors which play important roles in immune and CNS cell homeostasis, growth, and differentiation. Little is known about the effect of modulation of S1P5 due to the lack of S1P5 specific modulators with suitable druglike properties. Here we describe the discovery and optimization of a novel series of potent selective S1P5 antagonists and the identification of an orally active brain-penetrant tool compound 15.