18508-91-3

Upstream product

• 21862-63-5 trans-4-tert-butylcyclohexanol 
• 7143-01-3 Methanesulfonic anhydride 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 937-05-3 cis-4-tert-butyl-1-cyclohexanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1900-69-2 trans-4-tert-butylcyclohexyl acetate 
• 1621065-11-9 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-(trifluoromethyl)naphthalen-1-yl)methyl)piperidine-4-carboxylic acid 
• 1621065-12-0 2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-(trifluoromethyl)-1-naphthaldehyde 
• 1621065-13-1 ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-(trifluoromethyl)naphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1621065-14-2 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylic acid 
• 1621065-15-3 ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-iodonaphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1621065-16-4 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-chloronaphthalen-1-yl)methyl)piperidine-4-carboxylic acid 
• 1621065-17-5 ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-chloronaphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1621065-19-7 (R)-benzyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)pyrrolidine-3-carboxylate 
• 1621065-20-0 (S)-1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)pyrrolidine-3-carboxylic acid 
• 1621065-21-1 (S)-benzyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)pyrrolidine-3-carboxylate 
• 1621065-22-2 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid 
• 1621065-23-3 ethyl 1-((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1621064-61-6 2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methyl-1-naphthaldehyde 

Relevant academic research and scientific papers

COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS

Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).

Cyclopropenone catalyzed substitution of alcohols with mesylate ion

The cyclopropenone catalyzed nucleophilic substitution of alcohols by methanesulfonate ion with inversion of configuration is described. This work provides an alternative to the Mitsunobu reaction that avoids the use of azodicarboxylates and generation of hydrazine and phosphine oxide byproducts. This transformation is shown to be compatible with a range of functionality. A cyclopropenone scavenge strategy is demonstrated to aid purification.

S1P MODULATING AGENTS

Compounds of formula (I) or (II) can modulate the activity of SIP receptors.

BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS

Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SlP receptors.

A PROCEDURE FOR ALCOHOL INVERSION USING CESIUM ACETATE

A convenient and efficient procedure for alcohol inversion by means of the reaction of mesylates or alkyl halides with cesium acetate is described.