1621090-64-9Relevant articles and documents
6-Benzyloxyquinazolin-7-ylurea derivatives with an anticancer activity
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Paragraph 0126; 0127; 0128; 0129; 0130; 0132; 0133, (2018/02/28)
The present invention relates to a 6-benzyloxyquinazoline-7-ylurea derivative having anticancer activity and, more specifically, to a 6-benzyloxyquinazoline-7-ylurea derivative represented by chemical formula 1 and a compound selected from pharmaceuticall
Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: Cell line-based assay, kinase panel, molecular docking, and toxicity studies
Elkamhawy, Ahmed,Park, Jung-Eun,Cho, Nam-Chul,Sim, Taebo,Pae, Ae Nim,Roh, Eun Joo
, p. 158 - 166 (2016/01/12)
Herein, we report compound KST9046, a new agent possessing quinazoline-urea scaffold. Preliminary biological evaluation done by the National Cancer Institute (NCI), USA, showed a great inhibitory effect of KST9046 over the 60 cell-line tumor panel. Accord
Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: Design, synthesis, and molecular docking study
Elkamhawy, Ahmed,Lee, Jiyoun,Park, Beoung-Geon,Park, Insun,Pae, Ae Nim,Roh, Eun Joo
, p. 466 - 475 (2014/08/05)
A novel series of twenty-six quinazoline-urea derivatives was designed and synthesized. Their blocking activities against β-amyloid peptide (Aβ) induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which measured