1621182-18-0

Basic information

• Product Name: 6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]-3,4-dihydroquinazoline-4-one
• Synonyms: 6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]-3,4-dihydroquinazoline-4-one
• CAS NO: 1621182-18-0
• Molecular Weight: 277.236
• Mol File: 1621182-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]-3,4-dihydroquinazoline-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]-3,4-dihydroquinazoline-4-one(1621182-18-0)
• EPA Substance Registry System: 6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]-3,4-dihydroquinazoline-4-one(1621182-18-0)

Safety Data

• Hazardous Substances Data: 1621182-18-0(Hazardous Substances Data)

Upstream product

• 53449-14-2 7-chloro-6-nitro-4(3H)-quinazolinone 

Downstream Products

• 1621182-22-6 [¹⁸F](S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide 
• 314771-88-5 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 
• 850140-72-6 afatinib 
• 314771-76-1 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline 

Relevant articles and documents

RADIOLABELED QUINAZOLINE DERIVATIVES

Novel radiotracer for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging are described. Specifically, the invention relates to 18F-labeled afatinib suitable as a PET or SPECT tracer for imaging epidermal growth factor receptor (EGFR, erbB1) and human epidermal growth factor receptor 2 (Her2, erbB2), to a precursor compound for use in its synthesis, to methods for the preparation 18F-iabeled afatinib, as well as to the use thereof in in vivo diagnosis, tumor imaging or patient stratification on the basis of mutational status of EGFR (erbB1) and Her2 (erbB2).