1621326-32-6 Usage
General Description
(S)-3a-hydroxy-6-methyl-1-(4-nitrophenyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-b]quinolin-4-one, also known as NMDA receptor antagonist PNQX, is a chemical compound that acts as a selective competitive antagonist for the N-methyl-D-aspartate (NMDA) receptor. (S)-3a-hydroxy-6-methyl-1-(4-nitrophenyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-b]quinolin-4-one has been extensively studied for its potential therapeutic applications in treating various neurological disorders, including epilepsy, stroke, and neuropathic pain. Its ability to block the NMDA receptor, which is involved in the regulation of synaptic plasticity and memory formation, makes it a promising candidate for the development of new pharmacological interventions for these conditions. Studies have also shown that PNQX may have neuroprotective properties, making it potentially useful in preventing neuronal damage in neurological diseases. However, further research is needed to fully understand the potential benefits and risks of using this compound for clinical purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 1621326-32-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,1,3,2 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1621326-32:
(9*1)+(8*6)+(7*2)+(6*1)+(5*3)+(4*2)+(3*6)+(2*3)+(1*2)=126
126 % 10 = 6
So 1621326-32-6 is a valid CAS Registry Number.
1621326-32-6Relevant articles and documents
Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs
Verhasselt, Sigrid,Roman, Bart I.,Bracke, Marc E.,Stevens, Christian V.
, p. 85 - 103 (2017/05/10)
(S)-Blebbistatin is a widely used research tool to study myosin II, an important regulator of many motility based diseases. Its potency is too low to be of clinical relevance, but identification of analogs with enhanced potency could deliver leads for tar
