16214-99-6Relevant articles and documents
Synthesis of cis-3-methyl-4-aminopiperidine derivatives
Hilario, Flaviane Francisco,Santos, Daniela Cristina Dos,Gil, Laurent Frederic,Alves, Rosemeire Brondi,De Freitas, Rossimiriam Pereira
, p. 1184 - 1193 (2008)
A facile approach for the preparation of cis-3-methyl-4-aminopiperidine derivatives is described. The synthesis was carried out via regioselective ring opening of N-benzyl-3-methyl-3,4-epoxi-piperidine (8), which can be easily obtained in two steps from t
Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
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Page/Page column 24, (2010/02/14)
The present invention relates to alkyne compounds of general formula I wherein the groups and radicals A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one alkyne according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.