16214-99-6

Usage

Chemical class

Pyridinium class of compounds

Common use

Quaternary ammonium compound

Application

Phase-transfer catalyst in organic synthesis

Antimicrobial properties

Used as an antiseptic and disinfectant

Fields of use

Medicine and industrial processes

Potential use

Pharmaceutical applications

Additional application

Inhibiting the growth of bacterial biofilms

Physical state

Typically a white solid

Solubility

Soluble in polar solvents such as water and methanol

Upstream product

• 108-99-6 3-Methylpyridine 
• 100-44-7 benzyl chloride 
• 3287-99-8 benzylamine hydrochloride 

Downstream Products

• 63065-67-8 2-benzyl-5-methyl pyridine 
• 24015-80-3 3-methyl-4-benzylpyridine 
• 56664-26-7 2-benzyl-3-methylpyridine 
• 40240-24-2 1-benzyl-5-methyl-1,2,3,6-tetrahydropyridine 
• 74975-25-0 4-benzoylpyridine-3-carboxylic acid 
• 162465-70-5 1-benzyl-4-methoxy-3-methyl-1,4,5,6-tetrahydropyridine 
• 212008-99-6 1-benzyl-3-methyl-1,2,5,6-tetrahydropyridine N-oxide 

Relevant academic research and scientific papers

Synthesis of cis-3-methyl-4-aminopiperidine derivatives

A facile approach for the preparation of cis-3-methyl-4-aminopiperidine derivatives is described. The synthesis was carried out via regioselective ring opening of N-benzyl-3-methyl-3,4-epoxi-piperidine (8), which can be easily obtained in two steps from t

Reaction of aldimine anions with vinamidinium chloride: Three-component access to 3-alkylpyridines and 3-alkylpyridinium salts and access to 2-alkyl glutaconaldehyde derivatives

(Chemical Equation Presented) N-tert-Butylimino derivatives of aldehydes were deprotonated with LDA and reacted with vinamidinium chloride to give 2-alkylaminopentadienimine derivatives, which were isolated as their corresponding hydrochloride in 68-81% yield. Reaction of these derivatives with ammonium acetate or salts of primary amines, in n-butanol at 80°C, afforded the corresponding 3-alkylpyridines or 3-alkylpyridinium salts in high yield. Alkaline hydrolysis of 2-alkylaminopentadieneimine derivatives allowed a practical accesss to potassium salts of 2-alkylglutaconaldehyde.

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

The present invention relates to alkyne compounds of general formula I wherein the groups and radicals A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one alkyne according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.

NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS CONTAINING SAID COMPOUNDS

The invention relates to alkyne compounds of general formula (I), in which the groups and radicals A, B, W, X, Y, Z, R1 and R2 are defined as cited in claim 1. The invention also relates to medicaments containing at least one inventive alkyne. As a result of the antagonistic action against the MCH-receptor, the inventive medicaments are suitable for treating metabolic disorders and/or eating disorders, in particular adiposity and diabetes.