1621431-72-8

Basic information

• Product Name: 6-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline
• Synonyms: 6-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline
• CAS NO: 1621431-72-8
• Molecular Weight: 313.334
• Mol File: 1621431-72-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 6-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline(1621431-72-8)
• EPA Substance Registry System: 6-(4-fluorophenyl)pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline(1621431-72-8)

Safety Data

• Hazardous Substances Data: 1621431-72-8(Hazardous Substances Data)

Upstream product

• 405-50-5 p-Fluorophenylacetic acid 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 115769-03-4 2-(2-bromophenyl)imidazo[1,2-α]pyridine 
• 49851-55-0 2,2'-dibromoacetophenone 
• 552-89-6 2-nitro-benzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 126267-63-8 2-(2-nitro-phenyl)-imidazo[1,2-a]pyridine 
• 253684-24-1 1-(2,2-dibromovinyl)-2-nitrobenzene 
• 504-29-0 2-aminopyridine 

Relevant articles and documents

Synthesis of Pyrido-Fused Imidazo[4,5-c]quinolines by I2-DMSO Promoted Oxidative Cross Coupling and Intramolecular Cyclization

The synthesis of a series of novel quinoline fused imidazo[4,5-c]quinolines was accomplished by a simple, efficient, iodine-dimethyl- sulfoxide (I2-DMSO) promoted sequential oxidative cross coupling- followed by intramolecular cyclization of py

Molecular iodine-catalysed oxidative CO-C(alkyl) bond cleavage of aryl/heteroaryl alkyl ketones: an efficient strategy to access fused polyheterocycles

An efficient molecular iodine-catalysed one-pot strategy has been accomplished for the construction of various fused heterocycles such as pyridoimidazoles, pyrrolo[1,2-a]quinoxalines and imidazobenzothiazoles under metal and oxidant free conditions. Gratifyingly, this method allows the sequential formation of C-N and C-C bonds with concomitant CO-C(alkyl) bond cleavage. The key features of this protocol are a broad substrate scope, operational simplicity, good to moderate yields and metal-free conditions, which make this protocol convenient for the generation of a library of fused polyheterocycles.

Synthesis of biologically active pyridoimidazole/imidazobenzothiazole annulated polyheterocycles using cyanuric chloride in water

An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in an aqueous reaction medium has been developed. The protocol was successfully applied to a wide range of compounds including aryl/heteroaryl aldehydes (8a-o), ketones (10a-e), an electron-rich metallocene aldehyde (8e) and indoline-2,3-diones (12a-c) using cyanuric chloride (15-20 mol%) with tetra-n-butylammonium bromide (TBAB) (2.0 eq.) as an additive at 80-90 °C to give a good to excellent yield (66-92%) of polyheterocycles. Some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine-sensitive (CQ-S) 3D7 and chloroquine-resistant (CQ-R) K1 strains of Plasmodium falciparum. This journal is the Partner Organisations 2014.