1622-54-4Relevant articles and documents
Facile Synthesis of 9,10-Dihydro-4H-Benzo [4,5] Cyclohepta [1,2-b] Thiophene-4-One: A Crucial Drug Intermediate-Application of Wittig-Horner Reaction
Murty,Ramalingam,Sabitha,Yadav
, p. 449 - 454 (2001)
Synthesis of 9,10-dihydro-4H-benzo [4,5] cyclohepta[1,2-b] thiophene-4-one, a key pharmaceutical intermediate was described by two different routes. The formation of Cannizzaro reaction products was observed in first route. Wittig-Horner reaction conditions were utilized in the second route to obtain the title compound in good yield.
The Effects of Stereochemistry of the Bridging Atoms in o-Substituted Arylbenzoic Acids on Root Antigravitropism
Teitei, Tsutomu
, p. 1461 - 1466 (2007/10/02)
Compounds in which an aryl or heteroaryl ring is linked to the ortho position of a benzoic acid moiety by a bridging group of up to four atoms are shown to inhibit the gravitropic response of cress seedling roots between 1E-5 and 1E-8 M.No significant difference in inhibitory activity is observed between compounds containing up to four saturated or two partially unsaturated bridging atoms, although analogues containing three or four partially unsaturated bridging atoms are one to two orders of magnitude more active.Compounds in which the aryl nuclei are fused together are shown to be inactive at the highest concentration tested.The results have been interpreted in terms of the aryl groups in the molecule interacting with a hypothetical receptor site, with the bridging atoms acting as a more or less flexible coupling to facilitate such interaction.
