1622-54-4

Usage

Uses

Used in Pharmaceutical Research:
2-[2-(2-Thienyl)ethyl]benzoic acid is used as a key building block in pharmaceutical research for the development of novel therapeutic agents. Its unique structure allows for the synthesis of various organic compounds with potential applications in treating a range of inflammatory and metabolic disorders.
Used in Organic Synthesis:
In the field of organic synthesis, 2-[2-(2-Thienyl)ethyl]benzoic acid serves as a valuable precursor for the creation of new organic compounds. Its reactivity and structural features make it an ideal candidate for the synthesis of complex molecules with potential pharmaceutical applications.
Used in the Treatment of Inflammatory and Metabolic Disorders:
2-[2-(2-Thienyl)ethyl]benzoic acid has been studied for its potential therapeutic applications in the treatment of various inflammatory and metabolic disorders. Its biological activities and ability to modulate key pathways involved in these conditions make it a promising candidate for further research and development.
Overall, 2-[2-(2-Thienyl)ethyl]benzoic acid is a versatile and valuable chemical with significant implications in both research and industry. Its unique properties and potential applications in pharmaceutical research, organic synthesis, and the treatment of various disorders highlight its importance in the field of chemistry and medicine.

InChI:InChI=1/C13H12O2S/c14-13(15)12-6-2-1-4-10(12)7-8-11-5-3-9-16-11/h1-6,9H,7-8H2,(H,14,15)

Upstream product

• 1966-89-8 2-[2-(thienyl)vinyl] benzoic acid 
• 59636-00-9 (o-ethoxycarbonylbenzyl)triphenylphosphonium bromide 
• 98-03-3 thiophene-2-carbaldehyde 
• 216368-49-9 2-(diethoxy-phosphorylmethyl)-benzoic acid methyl ester 
• 2417-73-4 methyl 2-bromomethylbenzoate 
• 89-71-4 2-Methyl-benzoic acid methyl ester 

Downstream Products

• 1622-55-5 9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-4-one 

Relevant academic research and scientific papers

Facile Synthesis of 9,10-Dihydro-4H-Benzo [4,5] Cyclohepta [1,2-b] Thiophene-4-One: A Crucial Drug Intermediate-Application of Wittig-Horner Reaction

Synthesis of 9,10-dihydro-4H-benzo [4,5] cyclohepta[1,2-b] thiophene-4-one, a key pharmaceutical intermediate was described by two different routes. The formation of Cannizzaro reaction products was observed in first route. Wittig-Horner reaction conditions were utilized in the second route to obtain the title compound in good yield.

Reductive cleavage of phthalides with iodotrimethylsilane

A convenient reductive cleavage of 3-arylphthalides 1 into corresponding 2-benzylbenzoic acids and 2-(2-thienylmethyl)benzoic acid 2 by using iodotrimethylsilane is described.

The Effects of Stereochemistry of the Bridging Atoms in o-Substituted Arylbenzoic Acids on Root Antigravitropism

Compounds in which an aryl or heteroaryl ring is linked to the ortho position of a benzoic acid moiety by a bridging group of up to four atoms are shown to inhibit the gravitropic response of cress seedling roots between 1E-5 and 1E-8 M.No significant difference in inhibitory activity is observed between compounds containing up to four saturated or two partially unsaturated bridging atoms, although analogues containing three or four partially unsaturated bridging atoms are one to two orders of magnitude more active.Compounds in which the aryl nuclei are fused together are shown to be inactive at the highest concentration tested.The results have been interpreted in terms of the aryl groups in the molecule interacting with a hypothetical receptor site, with the bridging atoms acting as a more or less flexible coupling to facilitate such interaction.