1622136-46-2

Usage

Uses

Used in Pharmaceutical Industry:
(S)-praziquanamine-hemi-dibenzoyl-L-tataric acid salt is used as an anthelmintic agent for the treatment of parasitic infections. Its improved solubility and bioavailability make it a more effective and convenient option for oral administration, potentially leading to better patient compliance and treatment outcomes.
Used in Research and Development:
(S)-praziquanamine-hemi-dibenzoyl-L-tataric acid salt is also used in the research and development of new treatments for parasitic infections. Its enhanced properties may lead to the discovery of more effective drugs and therapies for a range of helminth infections, contributing to the advancement of medical science in this field.

Upstream product

• 2743-38-6 O,O'-dibenzoyl-L-tartaric acid 
• 61196-37-0 2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one 
• 17026-42-5 O,O'-dibenzoyl-D-tartaric acid 

Downstream Products

• 55375-92-3 (R)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one 
• 99746-73-3 (S)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one 
• 1399880-38-6 (R)-2-(cyclohexane-d11-carbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one 

Relevant academic research and scientific papers

Optically active [...][...] and the corresponding method for the preparation of the

The invention provides a preparation method of pyrazino amine salt with optical activity. The preparation method is characterized in that pyrazino amine salt is prepared through the reaction of racemic pyrazino amine and dibenzoyltartaric acid with optical activity in the presence of a solvent, wherein the solvent comprises more than 50% of 2-butanone in volume fraction; and dibenzoyltartaric acid with optical activity is diphenyl diketone-L-tartaric acid with optical impurity not less than 95%, or diphenyl diketone-D-tartaric acid with optical impurity not less than 95%. The invention also provides a preparation method of corresponding pyrazino amine with optical activity. The method performed for separating racemic pyrazino amine is very suitable for industrial application.

Methods of use comprising deuterated pyrazino[2,1-a]isoquinolines

This invention in one embodiment is directed to a compound of Formula Ia; where the designation (R) indicates that the designated carbon has the (R) stereochemistry; and wherein Z1 is hydrogen or fluorine; Z2 is hydrogen, deuterium,

Development and validation of process for resolution of praziquantel amine for preparation of chiral praziquantel

Investigation of the viability of scale up preparation for chiral praziquantel was included in WHO/TDR business plan. Resolution is the major strategy for preparation of single enantiomer. In this study, a stable and effective resolution approach toward the important intermediate praziquantel amine for preparation of chiral praziquantel was developed and the process was optimized to afford high ee value and good yield. The suitable HPLC method was validated for the determination of ee value of chiral praziquantel amine.