1622869-29-7

Basic information

• Product Name: C₂₃H₁₉F₃N₂O₃
• Synonyms: C₂₃H₁₉F₃N₂O₃
• CAS NO: 1622869-29-7
• Molecular Weight: 428.411
• Mol File: 1622869-29-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₉F₃N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₉F₃N₂O₃(1622869-29-7)
• EPA Substance Registry System: C₂₃H₁₉F₃N₂O₃(1622869-29-7)

Safety Data

• Hazardous Substances Data: 1622869-29-7(Hazardous Substances Data)

Upstream product

• 349122-10-7 C₁₅H₁₄N₂O₄ 
• 42926-52-3 2-ethoxybenzoyl chloride 
• 99-09-2 3-nitro-aniline 
• 953730-41-1 C₁₅H₁₆N₂O₂ 
• 312-94-7 2-trifluoromethylbenzoyl chloride 

Relevant articles and documents

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold

TASK-1 is a two-pore domain potassium channel that is important to modulating cell excitability, most notably in the context of neuronal pathways. In order to leverage TASK-1 for therapeutic benefit, its physiological role needs better characterization; however, designing selective inhibitors that avoid the closely related TASK-3 channel has been challenging. In this study, a series of bis-amide derived compounds were found to demonstrate improved TASK-1 selectivity over TASK-3 compared to reported inhibitors. Optimization of a marginally selective hit led to analog 35 which displays a TASK-1 IC 50 = 16 nM with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.