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162290-05-3

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162290-05-3 Usage

General Description

7,3'-Dihydroxy-4'-Methoxyflavan is a chemical compound belonging to the flavan class of flavonoids. It is a type of plant-derived compound with antioxidant properties and is found in various natural sources, including fruits, vegetables, and tea. Studies have shown that 7,3'-Dihydroxy-4'-Methoxyflavan has potential health benefits, including anti-inflammatory and cardioprotective effects. Its antioxidant activity may also help protect cells from damage caused by free radicals. Additionally, this compound has shown potential in the treatment of various diseases and conditions, making it a subject of interest for further research and development in the pharmaceutical and nutraceutical industries.

Check Digit Verification of cas no

The CAS Registry Mumber 162290-05-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,2,9 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 162290-05:
(8*1)+(7*6)+(6*2)+(5*2)+(4*9)+(3*0)+(2*0)+(1*5)=113
113 % 10 = 3
So 162290-05-3 is a valid CAS Registry Number.

162290-05-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 7,3'-Dihydroxy-4'-methoxyflavan

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:162290-05-3 SDS

162290-05-3Downstream Products

162290-05-3Relevant articles and documents

Enantioselective Synthesis of 2′- and 3′-Substituted Natural Flavans by Domino Asymmetric Transfer Hydrogenation/Deoxygenation

Ke?berg, Anton,Metz, Peter

, p. 6500 - 6503 (2016)

A concise and highly enantioselective synthesis of the natural flavans kazinol U and (2S)-7,3′-dihydroxy-4′-methoxyflavan is reported for the first time. The key transformation is a single-step conversion of a racemic flavanone to a flavan by means of an asymmetric transfer hydrogenation/deoxygenation cascade with kinetic resolution.

Identification of Interleukin-8-Reducing Lead Compounds Based on SAR Studies on Dihydrochalcone-Related Compounds in Human Gingival Fibroblasts (HGF-1 cells) in Vitro

Hans, Joachim,Ley, Jakob P.,Pfeiffer, Stefanie,Schueller, Katharina,Somoza, Veronika,Walker, Jessica

, (2020/03/26)

Background: In order to identify potential activities against periodontal diseases, eighteen dihydrochalcones and structurally related compounds were tested in an established biological in vitro cell model of periodontal inflammation using human gingival fibroblasts (HGF-1 cells). Methods: Subsequently to co-incubation of HGF-1 cells with a bacterial endotoxin (Porphyromonas gingivalis lipopolysaccharide, pgLPS) and each individual dihydrochalcone in a concentration range of 1 μM to 100 μM, gene expression of interleukin-8 (IL-8) was determined by qPCR and cellular interleukin-8 (IL-8) release by ELISA. Results: Structure–activity analysis based on the dihydrochalcone backbone and various substitution patterns at its aromatic ring revealed moieties 20,4,40,60-tetrahydroxy 3-methoxydihydrochalcone (7) to be the most effective anti-inflammatory compound, reducing the pgLPS-induced IL-8 release concentration between 1 μM and 100 μM up to 94%. In general, a 2,4,6-trihydroxy substitution at the A-ring and concomitant vanilloyl (4-hydroxy-3-methoxy) pattern at the B-ring revealed to be preferable for IL-8 release inhibition. Furthermore, the introduction of an electronegative atom in the A,B-linker chain led to an increased anti-inflammatory activity, shown by the potency of 4-hydroxybenzoic acid N-vanillylamide (13). Conclusions: Our data may be feasible to be used for further lead structure designs for the development of potent anti-inflammatory additives in oral care products.

Studies on flavans. III. The total synthesis of (±)-7,4′ -dihydroxy-3′-methoxyflavan, (±)-7,3′-dihydroxy-4′ -methoxyflavan, and (±)-7,4′-dihdroxyflavan

Xue, Jijun,Zhang, Xianshu,Chen, Xuesong,Zhang, Yingpeng,Li, Ying

, p. 3527 - 3536 (2007/10/03)

The first total synthesis of (±)-7,3′-dihydroxy-4′ -methoxyflavan (1) and (±)-7,4′-dihydroxy-3′-methoxyflavan (2), along with the synthesis of (±)-7,4′-dihydroxyflavan (3), three naturally occurring flavans, were described. The key step is the cyclization of 1,3-diaryl-1-propanol by BF3·Et2O.

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