408529-30-6

Basic information

• Product Name: 1-(4-methoxy-3-(methoxymethoxy)phenyl)ethanone
• Synonyms: 1-(4-methoxy-3-(methoxymethoxy)phenyl)ethanone
• CAS NO: 408529-30-6
• Molecular Weight: 210.23
• Mol File: 408529-30-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxy-3-(methoxymethoxy)phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxy-3-(methoxymethoxy)phenyl)ethanone(408529-30-6)
• EPA Substance Registry System: 1-(4-methoxy-3-(methoxymethoxy)phenyl)ethanone(408529-30-6)

Safety Data

• Hazardous Substances Data: 408529-30-6(Hazardous Substances Data)

Upstream product

• 6100-74-9 3-hydroxy-4-methoxyacetophenone 
• 107-30-2 chloromethyl methyl ether 
• 618895-97-9 1-(4-methoxy-3-methoxymethoxyphenyl)ethanol 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 5779-98-6 O-methoxymethylisovanillin 
• 621-59-0 isovanillin 

Downstream Products

• 162290-05-3 (+/-)-7,3'-dihydroxy-4'-methoxyflavan 
• 618896-06-3 (+/-)-7,3'-dimethoxymethoxy-4'-methoxyflavan 
• 618896-04-1 1-(4-methoxy-3-methoxymethoxyphenyl)-3-(2,4-dimethoxyphenyl)-1-propanol 
• 634922-71-7 2,3',4-trimethoxymethoxy-4'-methoxychalcone 

Relevant articles and documents

Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin

By fusing donepezil and curcumin, a novel series of compounds were obtained as multitarget-directed ligands against Alzheimer's disease. Among them, compound 11b displayed potent acetylcholinesterase (AChE) inhibition (IC50?=?187?nM) and the highest BuChE/AChE selectivity (66.3). Compound 11b also inhibited 45.3% Aβ1–42 self-aggregation at 20?μM and displayed remarkable antioxidant effects. The metal-chelating property of compound 11b was elucidated by determining the 1:1 stoichiometry for the 11b–Cu(II) complex. The excellent blood–brain barrier permeability of 11b also indicated the potential for the compound to penetrate the central nervous system.