5779-98-6

Basic information

• Product Name: Benzaldehyde, 4-methoxy-3-(methoxymethoxy)-
• CAS NO: 5779-98-6
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Mol File: 5779-98-6.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-methoxy-3-(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-methoxy-3-(methoxymethoxy)-(5779-98-6)
• EPA Substance Registry System: Benzaldehyde, 4-methoxy-3-(methoxymethoxy)-(5779-98-6)

Safety Data

• Hazardous Substances Data: 5779-98-6(Hazardous Substances Data)

Upstream product

• 621-59-0 isovanillin 
• 616-38-6 carbonic acid dimethyl ester 
• 13057-17-5 bromethyl methyl ether 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 109-87-5 Dimethoxymethane 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 110048-34-5 6-methoxy-2-(4-methoxy-3-methoxymethoxy-phenyl)-chroman-4-one 
• 19826-54-1 E-1-(phenyl)-2-(3'-hydroxy-4'-methoxyphenyl)ethene 
• 944828-50-6 1-(2,3,4-trimethoxy-6-methoxymethoxyphenyl)-3-(4-methoxy-3-methoxymethoxyphenyl)-2-propen-1-one 
• 1236355-33-1 (E,E)-3,5-bis-(3'-hydroxy-4'-methoxystyryl)benzene 
• 1447605-55-1 C₃₂H₃₀O₇ 
• 1365537-52-5 C₃₈H₄₈O₈Si 
• 4049-38-1 eriodictyol 

Relevant articles and documents

Bioinspired Diastereoconvergent Synthesis of the Tricyclic Core of Palodesangrens via Diels-Alder Reaction, LiAlH4-Mediated Isomerization, and Acid-Mediated Cyclization

The cyclohexene moiety of the tricyclic 6,7-diaryl-tetrahydro-6H-benzo[c]chromene core of palodesangrens could be assembled in a biomimetic and step-economical fashion by the Diels-Alder reaction between the electron-rich (E)-1,3-butadienylarenes as the diene and the electron-deficient chalcones as the dienophile. During the reduction of ketone to the corresponding alcohol by LiAlH4, the mixture of endo and exo isomers underwent a novel diastereoconvergent LiAlH4-mediated isomerization to install the desired stereochemistry at C10a. Subsequent pyran ring closure under acidic conditions installed the stereochemistry at the remaining C6. Overall, the tricyclic core of palodesangrens could be prepared in three steps and up to 38% yield.

Eriodictyol synthesis method

The invention provides an eriodictyol synthesis method. According to the eriodictyol synthesis method, isovanillin and 2,4,6-trihydroxyacetophenone are selected as starting materials, and eriodictyol is obtained through the following five steps: firstly, performing MOMCl protection on a hydroxyl of isovanillin; secondly, performing MOMCl protection on a hydroxyl of 2,4,6-trihydroxyacetophenone; thirdly, performing an aldol condensation reaction to generate chalcone; fourthly, performing Michael addition and cyclization; finally, carrying out MOM deprotection to obtain eriodictyol of which the total yield is 50-65%. As isovanillin and 2,4,6-trihydroxyacetophenone are selected as the starting materials, the eriodictyol synthesis method is high in yield and suitable for industrialized production.

Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents

A new and efficient total synthesis has been developed to obtain plagiochin G (22), a macrocyclic bisbibenzyl, and four derivatives. The key 16-membered ring containing biphenyl ether and biaryl units was closed via an intramolecular SNAr reaction. All synthesized macrocyclic bisbibenzyls inhibited Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and, thus, are potential cancer chemopreventive agents.