1623153-58-1

Basic information

• Product Name: 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-fluorophenyl)urea
• Synonyms: 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-fluorophenyl)urea
• CAS NO: 1623153-58-1
• Molecular Weight: 427.454
• Mol File: 1623153-58-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-fluorophenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-fluorophenyl)urea(1623153-58-1)
• EPA Substance Registry System: 1-(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)-3-(4-fluorophenyl)urea(1623153-58-1)

Safety Data

• Hazardous Substances Data: 1623153-58-1(Hazardous Substances Data)

Upstream product

• 959616-74-1 tert-butyl (1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate 
• 1623153-48-9 2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl trifluoromethanesulfonate 
• 1351401-26-7 7-fluoro-1-(2-hydroxyethyl)-1,5-naphthyridin-2(1H)-one 
• 959617-72-2 1-(2-(4-aminopiperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one 
• 1195-45-5 para-fluorophenyl isocyanate 
• 959615-64-6 7-fluoro-1,5-naphthyridin-2(1H)-one 
• 884495-37-8 2-chloro-5-fluoro-3-nitropyridine 

Relevant articles and documents

Extending the N-linked aminopiperidine class to the mycobacterial gyrase domain: Pharmacophore mapping from known antibacterial leads

Bacterial DNA gyrase is a well-established and clinically validated target to develop novel antibacterial. Our effort was designated to search for synthetically better compounds with possibility of hit to lead development. With this as objective, a series of 1-(2-(4-aminopiperidin-1-yl)ethyl)-1,5- naphthyridin-2(1H)-one derivatives were designed by molecular hybridization strategy and synthesized following nine step reaction to yield activity in low nanomolar range and commendable antibacterial activities. Compound 1-(4-fluorophenyl)-3-(1-(2-(7-methoxy-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl) piperidin-4-yl)urea (35) emerged as the most promising inhibitor with an IC 50 of 78 nM against Mycobacterium tuberculosis DNA gyrase enzyme, with MTB MIC of 0.62 μM, and not cytotoxic at 50 μM in eukaryotic cell line.