162337-94-2Relevant articles and documents
A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1] heptanes
Hassner, Alfred,Belostotskii, Anatoly M.
, p. 1709 - 1712 (2007/10/02)
Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.
