173906-89-3Relevant academic research and scientific papers
Synthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones
Diaba, Fa?za,Montiel, Juan A.,Serban, Georgeta,Bonjoch, Josep
, p. 3860 - 3863 (2015)
An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-typ
A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1] heptanes
Hassner, Alfred,Belostotskii, Anatoly M.
, p. 1709 - 1712 (2007/10/02)
Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.
