1623432-63-2

Basic information

• Product Name: (2S)-2-amino-2-cyclopropylethan-1-ol hydrochloride
• Synonyms: (2S)-2-amino-2-cyclopropylethan-1-ol hydrochloride
• CAS NO: 1623432-63-2
• Molecular Weight: 137.609
• Mol File: 1623432-63-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-2-amino-2-cyclopropylethan-1-ol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-amino-2-cyclopropylethan-1-ol hydrochloride(1623432-63-2)
• EPA Substance Registry System: (2S)-2-amino-2-cyclopropylethan-1-ol hydrochloride(1623432-63-2)

Safety Data

• Hazardous Substances Data: 1623432-63-2(Hazardous Substances Data)

Usage

General Description

(2S)-2-amino-2-cyclopropylethan-1-ol hydrochloride is a chemical compound that is often used in laboratory research and pharmaceutical development. It is the hydrochloride salt form of a chiral amino alcohol with a cyclopropyl group, making it a versatile building block for the synthesis of complex molecules. (2S)-2-amino-2-cyclopropylethan-1-ol hydrochloride exhibits both acidic and basic properties, and its structure allows for various chemical modifications, making it useful in the development of new drugs and other bioactive compounds. Additionally, it can be used as a chiral starting material for the synthesis of enantiomerically pure compounds, making it valuable in chemical and pharmaceutical industries.

Downstream Products

• 1640128-68-2 (2S)-2-((2R,3R)-3-(4-chloro-3-fluorophenyl)-2-(3-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-cyclopropyl-2-hydroxyethyl)-2-methylpent-4-enamide 
• 1623432-50-7 2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)-N-phenylacetamide 
• 1584731-41-8 2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetamide 
• 1584731-91-8 2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid chloride 
• 1352066-57-9 2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid 
• 1640128-71-7 (3S,5S,6R,8S)-8-allyl-6-(3-chlorophenyl)-5-(4-chlorophenyl)-3-cyclopropyl-8-methyl-2,3,5,6,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate 
• 1623432-52-9 (2S)-2-((2R,3R)-2-(3-chlorophenyl)-3-(4-chlorophenyl)-3-hydroxypropyl)-N-((S)-1-cyclopropyl-2-hydroxyethyl)-2-methylpent-4-enamide 
• 1584731-94-1 2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid 
• 1623432-67-6 (3S,5R,6S)-3-allyl-1-((S)-2-(tert-butylthio)-1-cyclopropylethyl)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methylpiperidin-2-one 
• 1623432-66-5 (3S,5S,6R,8S)-8-allyl-6-(3-chloro-2-fluorophenyl)-5-(4-chlorophenyl )-3-cyclopropyl-8-methyl-2 ,3, 5,6 ,7,8-hexahydrooxazolo[3,2-a]pyridin-4-ium 4-methylbenzenesulfonate 
• 1623432-64-3 (3S,5R,6S)-3-allyl-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-1-((S)-1-cyclopropyl-2-hydroxyethyl)-3-methylpiperidin-2-one 
• 1198185-81-7 (S)-2-amino-2-cyclopropylethan-1-ol 
• 1623432-51-8 4-(2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetamido)-2-methoxybenzoic acid 
• 1623432-68-7 methyl 4-(2-((3R,5R,6S)-1-((S)-2-(tert-butylsulfonyl)-1-cyclopropylethyl)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3-methyl-2-oxopiperidin-3-yl)acetamido)-2-methoxybenzoate 

Relevant articles and documents

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical properties, pharmacokinetic profile, in vivo efficacy, and safety profile. This optimization effort discovered 46, which met our target candidate profile. Compound 46 had excellent activity against cultured Plasmodium falciparum, and in vivo against P. falciparum and P. berghei in infected mice. It exhibited good PK properties in mice, rats, and dogs. It was highly active against the other 11 P. falciparum strains, which are mostly resistant to chloroquine and pyrimethamine. The rapid parasite in vitro reduction and in vivo parasite clearance profile of 46 were similar to those of artemisinin and chloroquine, two rapid-acting antimalarials. It was nongenotoxic in an Ames assay, an in vitro micronucleus assay, and an in vivo rat micronucleus assay when dosed orally up to 2000 mg/kg. The combined properties of this novel benzoxaborole support its progression to preclinical development.