16236-38-7

Upstream product

• 56705-83-0 4-(2-methylphenoxy)aniline 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 95-48-7 ortho-cresol 
• 2444-29-3 1-methyl-2-(4-nitrophenoxy)benzene 
• 67073-90-9 2,4,6-Tri-tert-butyl-4-o-tolyloxy-cyclohexa-2,5-dienone 
• 223655-23-0 4-methoxyphenoxy-2-methylbenzene 
• 100-00-5 4-chlorobenzonitrile 
• 4549-72-8 sodium o-cresolate 

Downstream Products

• 54758-77-9 1-(2'-tolyloxy)-4-[(4'-methyl)-benzyloxy]benzene 
• 274902-83-9 2-[2-(4-o-tolyloxy-phenoxy)-ethoxy]-tetrahydro-pyran 
• 274902-85-1 4-(2-methylphenoxy)phenoxyethyl 4-toluenesulfonate 
• 274902-84-0 4-(2-methylphenoxy)phenoxyethanol 
• 16236-36-5 <4-(3-Methyl-4-hydroxy-phenoxy)-phenyl>-<4-(2-methyl-phenoxy)-phenyl>-aether 

Relevant academic research and scientific papers

Method for selectively preparing hydroquinone monoether compound or quinol compound (by machine translation)

The method comprises the following steps: taking an organic boric acid compound and a p-benzoquinone compound as a reaction raw material, under the action of a copper catalyst, selectively reacting to obtain a hydroquinone monoether compound or a quinol compound. Compared with the prior art, the method disclosed by the invention adopts a one-pot reaction, can selectively obtain two products through solvent control, is suitable for preparing various types of hydroquinone monoether compounds and quinol compounds, and has wide applicability. The substrate functional group is high in tolerance and wide in substrate range. The raw material and the catalyst are cheap and easily available, the reaction conditions are mild, the reaction solvent is green and environment-friendly, the post-treatment is simple, and the yield and purity of the product are high. The preparation method is convenient. The method is rapid and efficient, and has a good application prospect in drug molecule synthesis. (by machine translation)

Design and synthesis of aryloxyethyl thiocyanate derivatives as potent inhibitors of Trypanosoma cruzi proliferation

As a part of our project directed at the search of new chemotherapeutic agents against American trypanosomiasis (Chagas' disease), several drugs possessing the 4-phenoxyphenoxy skeleton and other closely related structures employing the thiocyanate moiety as polar end group were designed, synthesized, and evaluated as antiproliferative agents against Trypanosoma cruzi, the parasite responsible for this disease. These thiocyanate analogues were envisioned bearing in mind the potent activity shown by 4- phenoxyphenoxyethyl thiocyanate (compound 8) taken as lead drug. This compound had previously proved to be an extremely active growth inhibitor against T. cruzi with IC50 values ranging from the very low micromolar level in epimastigotes to the low nanomolar level in the intracellular form of the parasite. Of the designed compounds, the ethyl thiocyanate drugs connected to nonpolar skeletons, namely, arylthio, 2,4-dichlorophenoxy, ortho-substituted aryloxy, and 2-methyl-4-phenoxyphenoxy (compounds 15, 34, 47, 52, 72, respectively), were shown to be very potent antireplicative agents against T. cruzi. On the other hand, conformationally restricted analogues as well as branched derivatives at the aliphatic side chain were shown to be moderately active against T. cruzi growth. The biological activity of drugs bearing the thiocyanate group correlated quite well with the activity exhibited by their normal precursors, the tetrahydropyranyl ether derivatives, when bonded to the same nonpolar skeleton. Compounds having the tetrahydropyranyl moiety as polar end were proportionally much less active than sulfur-containing derivatives in all cases. Drugs 47 and 72 also resulted to be very active against the amastigote form of the parasite growing in myoblasts; however, they were slightly less active than the lead drug 8. On the other hand, compounds 34 and 52 were almost devoid of activity against myoblasts. Surprisingly, the dithio derivative 15 was toxic for myoblasts.