4549-72-8

Basic information

• Product Name: sodium o-cresolate
• Synonyms: sodium o-cresolate;o-Cresol hydrochloride salt;Sodium 2-methylphenolate;Sodium 2-methylphenoxide
• CAS NO: 4549-72-8
• Molecular Formula: C₇H₇O*Na
• Molecular Weight: 130.11965
• EINECS: 224-914-6
• Mol File: 4549-72-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 516.7°Cat760mmHg
• Flash Point: 218.5°C
• Appearance: /
• Density: 1.03g/cm³
• CAS DataBase Reference: sodium o-cresolate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium o-cresolate(4549-72-8)
• EPA Substance Registry System: sodium o-cresolate(4549-72-8)

Safety Data

• Hazardous Substances Data: 4549-72-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8O.Na/c1-6-4-2-3-5-7(6)8;/h2-5,8H,1H3;/q;+1/p-1

Upstream product

• 95-48-7 ortho-cresol 
• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 
• 141-52-6 sodium ethanolate 

Downstream Products

• 578-58-5 2-methylmethoxybenzene 
• 71659-82-0 2-methyl-2-o-tolyloxypropionic acid ethyl ester 
• 100972-86-9 o-tolyloxy-malonic acid diethyl ester 
• 614-71-1 2-ethoxytoluene 
• 25173-35-7 3-(2-methylphenoxy)propanoic acid 
• 108973-39-3 6-methyl-4-o-tolyloxy-quinoline-1-oxide 
• 56207-30-8 formaldehyde di-o-tolylacetal 
• 934-21-4 1-vinyloxy-2-methylbenzene 
• 347-67-1 (2-chloro-1-fluoro-vinyl)-o-tolyl ether 
• 366-41-6 (2-chloro-1,1-difluoro-ethyl)-o-tolyl ether 
• 328-00-7 (2,2-dichloro-1,1-difluoro-ethyl)-o-tolyl ether 
• 859337-27-2 2-(1,2-dichloroethylenoxy)toluene 
• 1878-49-5 o-methylphenoxyacetic acid 
• 10345-39-8 O‐(o‐tolyl) dimethylcarbamothioate 

Relevant articles and documents

Ni-Catalyzed Aryl Sulfide Synthesis through an Aryl Exchange Reaction

A Ni-catalyzed aryl sulfide synthesis through an aryl exchange reaction between aryl sulfides and a variety of aryl electrophiles was developed. By using 2-pyridyl sulfide as a sulfide donor, this reaction achieved the synthesis of aryl sulfides without using odorous and toxic thiols. The use of a Ni/dcypt catalyst capable of cleaving and forming aryl-S bonds was important for the aryl exchange reaction between 2-pyridyl sulfides and aryl electrophiles, which include aromatic esters, arenol derivatives, and aryl halides. Mechanistic studies revealed that Ni/dcypt can simultaneously undergo oxidative additions of aryl sulfides and aromatic esters, followed by ligand exchange between the generated aryl-Ni-SR and aryl-Ni-OAr species to furnish aryl exchanged compounds.

Synthesis of enantiomerically pure 3-aryloxy-2-hydroxypropanoic acids, intermediate products in the synthesis of cis-4-Aminochroman-3-ols

Oxidation of accessible (R)-3-chloropropane-1,2-diol to (R)-3-chloro-2-hydroxypropanoic acid and subsequent reaction of the latter with ortho-substituted sodium phenoxide gave a number of enantiomerically pure 3-aryloxy-2-hydroxypropanoic acid which are intermediate products in the synthesis of nonracemic 4-aminochroman-3-ols.

Preparation of alkyl substituted o-hydroxybenzoic acid esters

A process for producing C1 -C5 alkyl substituted o-hydroxybenzoic acid esters comprising forming an anhydrous alkali metal phenolate-organic carrier mixture, carboxylating the phenolate by contacting the mixture with CO2 and reacting the resultant dialkali metal salt with 1 equivalent of an anhydrous acid/mole of salt and at least 1 mole of C1 -C5 alkyl chloride per mole of salt.