4549-72-8

Usage

InChI:InChI=1/C7H8O.Na/c1-6-4-2-3-5-7(6)8;/h2-5,8H,1H3;/q;+1/p-1

Upstream product

• 95-48-7 ortho-cresol 
• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 
• 141-52-6 sodium ethanolate 

Downstream Products

• 71659-82-0 2-methyl-2-o-tolyloxypropionic acid ethyl ester 
• 100972-86-9 o-tolyloxy-malonic acid diethyl ester 
• 25173-35-7 3-(2-methylphenoxy)propanoic acid 
• 108973-39-3 6-methyl-4-o-tolyloxy-quinoline-1-oxide 
• 934-21-4 1-vinyloxy-2-methylbenzene 
• 347-67-1 (2-chloro-1-fluoro-vinyl)-o-tolyl ether 
• 366-41-6 (2-chloro-1,1-difluoro-ethyl)-o-tolyl ether 
• 83-40-9 3-methylsalicylic acid 
• 78-30-8 tri-ortho-cresyl phosphate 
• 4592-97-6 2,3,5-trichloro-6-methyl-1,4-benzoquinone 
• 19578-70-2 benzyl 2-methylphenyl ether 
• 31040-70-7 6-benzyl-6-methylcyclohexa-2,4-dien-1-one 
• 70444-46-1 2-Methyl-4-trityl-phenol 
• 408331-40-8 o-tolyl-trityl ether 

Relevant academic research and scientific papers

Ni-Catalyzed Aryl Sulfide Synthesis through an Aryl Exchange Reaction

A Ni-catalyzed aryl sulfide synthesis through an aryl exchange reaction between aryl sulfides and a variety of aryl electrophiles was developed. By using 2-pyridyl sulfide as a sulfide donor, this reaction achieved the synthesis of aryl sulfides without using odorous and toxic thiols. The use of a Ni/dcypt catalyst capable of cleaving and forming aryl-S bonds was important for the aryl exchange reaction between 2-pyridyl sulfides and aryl electrophiles, which include aromatic esters, arenol derivatives, and aryl halides. Mechanistic studies revealed that Ni/dcypt can simultaneously undergo oxidative additions of aryl sulfides and aromatic esters, followed by ligand exchange between the generated aryl-Ni-SR and aryl-Ni-OAr species to furnish aryl exchanged compounds.

Preparation method of sodium o-methylphenoxyacetate in synthesis process of sodium 2-methyl-4-chlorophenoxyacetate

The invention relates to a preparation method of sodium o-methylphenoxyacetate in a synthesis process of sodium 2-methyl-4-chlorophenoxyacetate. The invention provides a preparation method of sodium o-methylphenoxyacetate, which comprises the following steps of: reacting o-cresol with sodium hydroxide to obtain a sodium o-cresol solution, reacting chloroacetic acid with sodium hydroxide to obtain a sodium chloroacetate solution, and reacting the sodium o-cresol with sodium chloroacetate under the condition of a catalyst to obtain the sodium o-methylphenoxyacetate. The catalyst is added in the preparation process, so that the reaction temperature and the decomposition rate of sodium chloroacetate can be effectively reduced, the conversion rate of o-cresol is improved, the problems of difficulty in later phenol-containing wastewater treatment and high energy consumption caused by low conversion rate of o-cresol are solved, and the preparation process is effectively simplified. Meanwhile, the sodium o-methylphenoxyacetate prepared by the preparation method is relatively high in purity and yield.

Synthesis of enantiomerically pure 3-aryloxy-2-hydroxypropanoic acids, intermediate products in the synthesis of cis-4-Aminochroman-3-ols

Oxidation of accessible (R)-3-chloropropane-1,2-diol to (R)-3-chloro-2-hydroxypropanoic acid and subsequent reaction of the latter with ortho-substituted sodium phenoxide gave a number of enantiomerically pure 3-aryloxy-2-hydroxypropanoic acid which are intermediate products in the synthesis of nonracemic 4-aminochroman-3-ols.

Process for the stereospecific synthesis of indole derivatives

The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: STR1 which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is condensed with a suitable primary amine in order to prepare an oxazolidinone and condensation with a suitable phenol, and the oxazolidinone ring is then opened to form an indole compound (I).

Preparation of alkyl substituted o-hydroxybenzoic acid esters

A process for producing C1 -C5 alkyl substituted o-hydroxybenzoic acid esters comprising forming an anhydrous alkali metal phenolate-organic carrier mixture, carboxylating the phenolate by contacting the mixture with CO2 and reacting the resultant dialkali metal salt with 1 equivalent of an anhydrous acid/mole of salt and at least 1 mole of C1 -C5 alkyl chloride per mole of salt.