1623774-90-2

Upstream product

• 5217-05-0 1-methylcyclopentanecarboxylic acid 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 622-79-7 benzyl azide 
• 1310826-33-5 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine 
• 20023-50-1 1-methylcyclopentanecarbonyl chloride 

Downstream Products

• 1623774-98-0 C₂₅H₃₀N₄O 

Relevant academic research and scientific papers

Iron-catalyzed C(sp2)-H and C(sp3)-H arylation by triazole assistance

Modular 1,2,3-triazoles enabled iron-catalyzed C-H arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp 2)-H functionalizations of arenes and alkenes with excellent chemo- and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3)-H functionalizations, and proceeds by an organometallic mode of action. The triazole-assisted C-H activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries. With a little help: A versatile iron catalyst allows the arylation of C(sp2)-H and C(sp3)-H bonds in the presence of a modular and removable triazolyldimethylmethyl (TAM) auxiliary, whose structure can be varied through 1,3-dipolar azide-alkyne cycloadditions.