5217-05-0

Basic information

• Product Name: Cyclopentanecarboxylic acid, 1-methyl-
• Synonyms: Cyclopentanecarboxylic acid, 1-methyl-;1-methylcyclopentanecarboxylic acid(SALTDATA: FREE);1-methyl-1-cyclopentanecarboxylic acid
• CAS NO: 5217-05-0
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.17
• Mol File: 5217-05-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 219°C (estimate)
• Flash Point: 103.1°C
• Appearance: /
• Density: 1.0218
• Refractive Index: 1.4529 (estimate)
• PKA: 5.00±0.20(Predicted)
• CAS DataBase Reference: Cyclopentanecarboxylic acid, 1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanecarboxylic acid, 1-methyl-(5217-05-0)
• EPA Substance Registry System: Cyclopentanecarboxylic acid, 1-methyl-(5217-05-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5217-05-0(Hazardous Substances Data)

Usage

General Description

Cyclopentanecarboxylic acid, 1-methyl-, is a chemical compound with the molecular formula C6H10O2. It is a carboxylic acid with a methyl group attached to the first carbon of the cyclopentane ring. Cyclopentanecarboxylic acid, 1-methyl- is used in the synthesis of pharmaceuticals and other organic compounds. It can also be used as an intermediate in the production of flavors and fragrances. Cyclopentanecarboxylic acid, 1-methyl-, is considered to be a stable and non-hazardous chemical with low toxicity.

Upstream product

• 6196-85-6 1-chloro-1-methylcyclopentane 
• 932-28-5 2-chloro-1-cyclopentylethan-1-one 
• 4630-83-5 methyl 1-methylcyclopentanecarboxylate 
• 201230-82-2 carbon monoxide 
• 108-93-0 cyclohexanol 
• 64-18-6 formic acid 
• 7664-93-9 sulfuric acid 
• 110-83-8 cyclohexene 
• 13388-93-7 1-(1-methyl-cyclopentyl)-ethanone 
• 3400-45-1 cyclopentanecarboxylic acid 
• 4630-80-2 methyl cyclopentane carboxylate 
• 108-94-1 cyclohexanone 
• 823-45-0 2-(hydroxymethylene)cyclohexanone 
• 37709-42-5 1-methyl-2-oxocyclohexane-1-carbaldehyde 

Downstream Products

• 20023-50-1 1-methylcyclopentanecarbonyl chloride 
• 38502-28-2 (1-methylcyclopentyl)methanol 
• 1429896-46-7 1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide 
• 5623-90-5 2-oxaspiro[4.4]nonane-1,3-dione 
• 70639-92-8 1-(1-methylcyclopentyl)-3-phenylprop-2-yn-1-one 
• 104543-92-2 C₁₉H₂₇NO₅ 
• 1623774-90-2 N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-1-methylcyclopentanecarboxamide 
• 1623774-98-0 C₂₅H₃₀N₄O 
• 1480750-55-7 N-(2-bromophenyl)-1-methylcyclopentanecarboxamide 
• 16747-50-5 1-ethyl-1-methyl-cyclopentane 
• 6140-63-2 1-methyl-1-cyclopentanecarbaldehyde 

Relevant articles and documents

Synthesis of Vicinal Quaternary All-Carbon Centers via Acid-catalyzed Cycloisomerization of Neopentylic Epoxides

We report our studies on the development of a catalytic cycloisomerization of 2,2-disubstituted neopentylic epoxides to produce highly substituted tetralins and chromanes. Termination of the sequence occurs via Friedel-Crafts-type alkylation of the remote (hetero)arene linker. The transformation is efficiently promoted by sulfuric acid and proceeds best in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as the solvent. Variation of the substitution pattern provided detailed insights into the migration tendencies and revealed a competing disproportionation pathway of dihydronaphthalenes.

3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction

Oxidative ring contraction of cyclic α-formyl ketones was facilitated by the action of H2O2under operationally simple and environmentally benign reaction conditions. The process was highly regioselective and enables stereospecific construction of contiguous quaternary all-carbon centers from stereodefined all-substituted all-cyclic ketones. The asymmetric syntheses of (+)-cuparene and (+)-tochuinyl acetate were also successively achieved by taking advantage of this novel protocol.