5217-05-0

Basic information

• Product Name: Cyclopentanecarboxylic acid, 1-methyl-
• Synonyms: Cyclopentanecarboxylic acid, 1-methyl-;1-methylcyclopentanecarboxylic acid(SALTDATA: FREE);1-methyl-1-cyclopentanecarboxylic acid
• CAS NO: 5217-05-0
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.17
• Mol File: 5217-05-0.mol

Chemical Properties

• Boiling Point: 219°C (estimate)
• Flash Point: 103.1°C
• Appearance: /
• Density: 1.0218
• Refractive Index: 1.4529 (estimate)
• PKA: 5.00±0.20(Predicted)
• CAS DataBase Reference: Cyclopentanecarboxylic acid, 1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanecarboxylic acid, 1-methyl-(5217-05-0)
• EPA Substance Registry System: Cyclopentanecarboxylic acid, 1-methyl-(5217-05-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5217-05-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Cyclopentanecarboxylic acid, 1-methyl-, is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drug molecules with potential therapeutic applications.
Used in Organic Compounds Synthesis:
Cyclopentanecarboxylic acid, 1-methylserves as a versatile building block in the synthesis of other organic compounds, contributing to the advancement of organic chemistry and the creation of novel materials with diverse properties.
Used in Flavors and Fragrances Production:
Cyclopentanecarboxylic acid, 1-methyl-, is employed as an intermediate in the production of flavors and fragrances, enhancing the sensory experience of various consumer products by imparting unique scents and tastes.
Used in Chemical Industry:
Due to its stability and low toxicity, Cyclopentanecarboxylic acid, 1-methyl-, finds applications in the chemical industry for the development of new compounds and materials with specific properties tailored for various uses.

Upstream product

• 13388-93-7 1-(1-methyl-cyclopentyl)-ethanone 
• 6196-85-6 1-chloro-1-methylcyclopentane 
• 932-28-5 2-chloro-1-cyclopentylethan-1-one 
• 110-83-8 cyclohexene 
• 108-93-0 cyclohexanol 
• 4630-83-5 methyl 1-methylcyclopentanecarboxylate 
• 109-94-4 formic acid ethyl ester 
• 201230-82-2 carbon monoxide 
• 64-18-6 formic acid 
• 7664-93-9 sulfuric acid 
• 3400-45-1 cyclopentanecarboxylic acid 
• 74-88-4 methyl iodide 
• 6553-72-6 ethyl 1-methyl-1-cyclopentanecarboxylate 
• 5453-85-0 ethyl cyclopentanecarboxylate 

Downstream Products

• 20023-50-1 1-methylcyclopentanecarbonyl chloride 
• 38502-28-2 (1-methylcyclopentyl)methanol 
• 13388-93-7 1-(1-methyl-cyclopentyl)-ethanone 
• 80605-95-4 1-Methylcyclopentylmethylketoxim-pikrat 
• 82322-86-9 2-Cyclohexyl-1-(1-methyl-cyclopentyl)-ethanone 
• 859181-91-2 1-methyl-cyclopentanecarboxylic acid phenyl ester 
• 16747-50-5 1-ethyl-1-methyl-cyclopentane 
• 1429896-46-7 1-(4-methoxybenzyl)-N-(quinolin-8-yl)cyclopentanecarboxamide 
• 70639-92-8 1-(1-methylcyclopentyl)-3-phenylprop-2-yn-1-one 
• 5623-90-5 2-oxaspiro[4.4]nonane-1,3-dione 
• 6140-63-2 1-methyl-1-cyclopentanecarbaldehyde 
• 1638-26-2 1,1-Dimethylcyclopentane 
• 104543-92-2 C₁₉H₂₇NO₅ 

Relevant articles and documents

Synthesis of Vicinal Quaternary All-Carbon Centers via Acid-catalyzed Cycloisomerization of Neopentylic Epoxides

We report our studies on the development of a catalytic cycloisomerization of 2,2-disubstituted neopentylic epoxides to produce highly substituted tetralins and chromanes. Termination of the sequence occurs via Friedel-Crafts-type alkylation of the remote (hetero)arene linker. The transformation is efficiently promoted by sulfuric acid and proceeds best in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as the solvent. Variation of the substitution pattern provided detailed insights into the migration tendencies and revealed a competing disproportionation pathway of dihydronaphthalenes.

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Provided are 5-(pyridin-3-yl) oxazole compounds, the compositions comprising these compounds and the uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

CASPASE INHIBITOR AND PHARMACEUTICAL COMPOSITION, USE AND THERAPEUTIC METHOD THEREOF

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3- (1H-PYRAZOL-4-YL) PYRIDINEALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Stereospecific Construction of Contiguous Quaternary All-Carbon Centers by Oxidative Ring Contraction

Oxidative ring contraction of cyclic α-formyl ketones was facilitated by the action of H2O2under operationally simple and environmentally benign reaction conditions. The process was highly regioselective and enables stereospecific construction of contiguous quaternary all-carbon centers from stereodefined all-substituted all-cyclic ketones. The asymmetric syntheses of (+)-cuparene and (+)-tochuinyl acetate were also successively achieved by taking advantage of this novel protocol.

New Strategy for Forging Contiguous Quaternary Carbon Centers via H 2 O 2 -Mediated Ring Contraction

Stereospecific construction of contiguous quaternary carbon centers constitutes a major challenge in natural product synthesis. A general protocol that enables stereospecific construction of all stereoisomers of such a moiety remains elusive. In this article, we will discuss the oxidative ring contraction of all-substituted cyclic α-formyl ketones mediated by H 2 O 2, which provides a facile access to the stereospecific construction of contiguous quaternary carbon centers.

Nickel-Catalyzed Addition-Type Alkenylation of Unactivated, Aliphatic C-H Bonds with Alkynes: A Concise Route to Polysubstituted γ-Butyrolactones

(Chemical Equation Presented). Through the nickel-catalyzed chelation-assisted C-H bond activation strategy, the addition-type alkenylation of unreactive β-C(sp3)-H bonds of aliphatic amides with internal alkynes is developed for the first time to produce γ,δ-unsaturated carboxylic amide derivatives. The resulting alkenylated products can further be transformed into polysubstituted γ-butyrolactones with pyridinium chlorochromate (PCC).

Palladium-catalyzed C(sp3)-H activation: A facile method for the synthesis of 3,4-dihydroquinolinone derivatives

3,4-Dihydroquinolinones were synthesized by the palladium-catalyzed, oxidative-addition-initiated activation and arylation of inert C(sp 3)-H bonds. Pd(OAc)2 and P(o-tol)3 were used as the catalyst and ligand, respectively, to improve the efficiency of the reaction. A further advantage of this reaction is that it could be performed in air. A relatively rare seven-membered palladacycle was proposed as a key intermediate of the catalytic cycle.

β-Arylation of carboxamides via iron-catalyzed C(sp3)-H bond activation

A 2,2-disubstituted propionamide bearing an 8-aminoquinolinyl group as the amide moiety can be arylated at the β-methyl position with an organozinc reagent in the presence of an organic oxidant, a catalytic amount of an iron salt, and a biphosphine ligand at 50 C. Various features of selectivity and reactivity suggest the formation of an organometallic intermediate via rate-determining C-H bond cleavage rather than a free-radical-type reaction pathway.