1623809-11-9Relevant academic research and scientific papers
Copper-Promoted 6- endo-trig Cyclization of β,γ-Unsaturated Hydrazones for the Synthesis of 1,6-Dihydropyridazines
Guo, Yong-Qiang,Zhao, Mi-Na,Ren, Zhi-Hui,Guan, Zheng-Hui
, p. 3337 - 3340 (2018/06/11)
A novel and efficient strategy for the synthesis of 1,6-dihydropyridazines via copper-promoted 6-endo-trig cyclization of readily available β,γ-unsaturated hydrazones have been developed. A series of 1,6-dihydropyridazines have been synthesized by this method with good yields, high functional group tolerance, and remarkable regioselectivity under mild conditions. Importantly, the 1,6-dihydropyridazines can be efficiently converted to biologically important pyridazines in the presence of NaOH.
Efficient synthesis of dihydropyrazoles by halocyclization of β,γ-unsaturated hydrazones
Hu, Xiao-Qiang,Chen, Jia-Rong,Wei, Qiang,Liu, Feng-Lei,Deng, Qiao-Hui,Zou, You-Quan,Xiao, Wen-Jing
supporting information, p. 3082 - 3086 (2014/06/09)
An efficient halocyclization of β,γ-unsaturated hydrazones with N-bromosuccinimide was developed without the addition of any additives under mild reaction conditions to provide facile access to biologically important 4,5-dihydropyrazoles. Under the optimized conditions, a variety of highly substituted 4,5-dihydropyrazole derivatives were obtained in generally good yields. Moreover, this reaction can be further applied to the synthesis of pyrazoles in a one-pot fashion. Copyright
