16240-00-9

Basic information

• Product Name: (2Z)-3-(2-methylphenyl)-2-[(2-methylphenyl)imino]-1,3-thiazolidin-4-one
• Synonyms: 3-(2-Methylphenyl)-2-((2-methylphenyl)imino)-1,3-thiazolidin-4-one; 4-thiazolidinone, 3-(2-methylphenyl)-2-[(2-methylphenyl)imino]-, (2Z)-
• CAS NO: 16240-00-9
• Molecular Formula: C₁₇H₁₆N₂OS
• Molecular Weight: 296.3867
• Mol File: 16240-00-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 444.3°C at 760 mmHg
• Flash Point: 222.5°C
• Density: 1.2g/cm³
• Vapor Pressure: 4.34E-08mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: (2Z)-3-(2-methylphenyl)-2-[(2-methylphenyl)imino]-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-3-(2-methylphenyl)-2-[(2-methylphenyl)imino]-1,3-thiazolidin-4-one(16240-00-9)
• EPA Substance Registry System: (2Z)-3-(2-methylphenyl)-2-[(2-methylphenyl)imino]-1,3-thiazolidin-4-one(16240-00-9)

Safety Data

• Hazardous Substances Data: 16240-00-9(Hazardous Substances Data)

Usage

General Description

The chemical (2Z)-3-(2-methylphenyl)-2-[(2-methylphenyl)imino]-1,3-thiazolidin-4-one, also known as thiazolidin-4-one, is a heterocyclic compound with a thiazolidine ring. It is a thiazolidinone derivative and has a molecular formula C15H15NOS. Thiazolidin-4-one has been studied for its potential pharmacological properties and has shown to possess anti-inflammatory, anticancer, and antimicrobial activities. It has been used in medicinal chemistry research for the development of new drugs and pharmaceuticals. Additionally, thiazolidin-4-one derivatives have been investigated for their potential as antioxidant and antidiabetic agents. However, further research is needed to fully understand the biological activities and potential applications of this compound.

Upstream product

• 19801-31-1 S-ethyl-N,N'-di-o-tolyl-isothiourea 
• 68-11-1 mercaptoacetic acid 
• 65252-02-0 S-methyl-N,N'-di-o-tolyl-isothiourea 
• 22695-18-7 N,N-di-o-tolylthiourea 
• 79-11-8 chloroacetic acid 
• 137-97-3 N,N'-di(o-tolyl)thiourea 
• 105-36-2 ethyl bromoacetate 
• 79-08-3 bromoacetic acid 
• 95-53-4 o-toluidine 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 102704-49-4 5-furfurylidene-3-o-tolyl-2-o-tolylimino-thiazolidin-4-one 
• 102754-25-6 5-benzylidene-2-(o-tolyl)imino-3-(o-tolyl)-thiazolidin-4-one 
• 304894-29-9 C₂₄H₂₀N₂O₂S 
• 1280723-04-7 4-(5-((4-oxo-3-(2-methylphenyl)-2-(2-methylphenylimino)thiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid 
• 1228044-60-7 3-(5-((4-oxo-3-(2-methylphenyl)-2-(2-methylphenylimino)thiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid 
• 617-07-2 N,N'-bis(2-methylphenyl)urea 
• 68-11-1 mercaptoacetic acid 
• 16240-02-1 3-o-tolylthiazolidine-2,4-dione 
• 114553-01-4 5-(4-dimethylamino-benzylidene)-3-o-tolyl-2-o-tolylimino-thiazolidin-4-one 

Relevant articles and documents

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Thiazolidione derivatives as novel antibiofilm agents: Design, synthesis, biological evaluation, and structure-activity relationships

Rational designed novel thiazolidiones were synthesized and evaluated for antibiofilm activity. The active derivatives were not only potent inhibitors of Staphylococcus epidermidis biofilm growth but also efficient antibacterial agents. 3f showed 4-fold higher activity (6.25 μM) in the biofilms dispersal assay and significantly higher antibacterial activity (MIC 3.125 μM) in comparison to the 3-(5-((6- (ethoxycarbonyl)-5-(benzo[1,3]dioxol-5-yl)-3-oxo-7- phenyl- thiazolo[3,2-a]pyrimidin-2(5H)-ylidene)methyl)furan-2-yl)benzoic acid (1).

Axially chiral 2-arylimino-3-aryl-thiazolidine-4-one derivatives: Enantiomeric separation and determination of racemization barriers by chiral HPLC

Axially chiral 2-arylimino-3-aryl-thiazolidine-4-ones have been synthesized as racemic mixtures, and each mixture with the exception of 2-(o-chlorophenyl)imino-3-(o-chlorophenyl)-thiazolidine-4-one has been converted to the corresponding 5-benzylidene-2-a