16241-15-9

Upstream product

• 16241-14-8 O-(2-(tert-butyl)phenyl) N,N-dimethylcarbamothioate 
• 88-18-6 2-tert-Butylphenol 

Downstream Products

• 19728-41-7 2-tert-butylthiophenol 
• 1027799-43-4 2-tert-butyl-N-(2,3-dihydro-1H-inden-2-yl)benzenesulfonamide 
• 1027010-95-2 tert-butyl 4-{[(2-tert-butylphenyl)sulfonyl]amino}piperidine-1-carboxylate 
• 19862-70-5 2-tert-butylphenyl disulfide 

Relevant academic research and scientific papers

SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE

Compounds of formula (I) and pharmaceutically acceptable salts thereof, which are modulators of secreted frizzled related protein- 1, are disclosed. The compounds, and compositions containing the compounds, can be used to treat various diseases and disord

N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1

Compounds of formula (I): Chemical formula should be inserted here as it appears on the abstract in paper form. and pharmaceutically acceptable salt thereof, which are modulators of secreted frizzled related protein-1, are disclosed. The compounds, and co

Rapid and Selective Reduction of Functionalized Aromatic Disulfides with Lithium Tri-tert-butoxyaluminohydride. A Remarkable Steric and Electronic Control. Comparison of Various Hydride Reagents

Lithium tri-tert-butoxyaluminohydride (LTBA), an exceptionally mild reducing agent in organic synthesis, reduces functionalized aromatic disulfides to the corresponding thiols in quantitative yield.The reaction is rapid (for example, o-tolyl disulfide is reduced to completion in 60 min at 25 deg C) and can tolerate a wide variety of functional groups, such as halogen, nitro, carboxylic acid, and their derivatives.The presence of electron-withdrawing substituents dramatically enhances the rate of reduction (p-chlorophenyl disulfide is quantitatively reduced in 30 s) and electron-releasing substituents diminishes the rate of cleavage.The reaction is sensitive to steric effects (2,4-di-tert-pentylphenyl disulfide underwent 25percent reduction in 24 h).However, such hindered disulfides can be rapidly and quantitatively reduced in refluxing THF.The reaction of LTBA with alkyl disulfides is extremely sluggish.The reaction provides a useful and simple means for the facile and selective reduction of aromatic disulfides where this is required in synthetic operations.