162465-32-9

Upstream product

• 162465-29-4 (5S)-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-(6R)-methyl-8-phenyl-(2E,7E)-octadienoic acid 
• 81176-43-4 (S)-trans-4-phenyl-3-buten-2-ol 
• 135758-87-1 (1S,2E)-benzoic acid 1-methyl-3-phenylallyl ester 
• 162465-28-3 (5S)-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-(6R)-methyl-8-phenyl-(2E,7E)-octadienoic acid methyl ester 
• 220554-70-1 (2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienoic acid methyl ester 
• 642087-12-5 (E)-(3S,4R)-3-Hydroxy-4-methyl-6-phenyl-hex-5-enal 
• 276870-03-2 (2R,4S,5R,6E)-5-methyl-7-phenyl-hept-6-ene-1,2,4-triol 

Downstream Products

• 155645-51-5 Cryptophycin 4 
• 162465-35-2 (S)-2-((R)-3-tert-Butoxycarbonylamino-2-methyl-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 162465-20-5 (R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester 

Relevant academic research and scientific papers

A synthesis of cryptophycin 4 using a planar chiral molybdenum cationic complex

A synthesis of cytotoxic agent Cryptophycin 4 features a new approach to (5S,6R)-5-hydroxy-6-methyl-8-phenyl-(2E,7E)-dienoic acid in which the anti stereochemistry between two stereogenic centres is secured by addition of a 1,3-dioxan-4-ylcopper(I) reagen

Total synthesis of cryptophycins. Revision of the structures of cryptophycins A and C

The convergent total synthesis of cryptophycins C and D is described. It has been shown that in both natural products the absolute configuration of the α-amino acid corresponds to the D-series. The structural assignment for cryptophycin C has been correct