135758-87-1

Upstream product

• 108-05-4 vinyl acetate 
• 36004-04-3 ethyl (E)-1-phenylbut-1-en-3-ol 
• 98-88-4 benzoyl chloride 
• 81176-43-4 (S)-trans-4-phenyl-3-buten-2-ol 
• 57194-69-1 cinnamaldehyde 

Downstream Products

• 276870-03-2 (2R,4S,5R,6E)-5-methyl-7-phenyl-hept-6-ene-1,2,4-triol 
• 155645-51-5 Cryptophycin 4 
• 162465-29-4 (5S)-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-(6R)-methyl-8-phenyl-(2E,7E)-octadienoic acid 
• 162465-28-3 (5S)-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-(6R)-methyl-8-phenyl-(2E,7E)-octadienoic acid methyl ester 
• 162465-20-5 (R)-2-((2E,7E)-(5S,6R)-5-Hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-3-(4-methoxy-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester 
• 162465-32-9 (R)-2-[(2E,7E)-(5S,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-8-phenyl-octa-2,7-dienoylamino]-3-(4-methoxy-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester 
• 162465-35-2 (S)-2-((R)-3-tert-Butoxycarbonylamino-2-methyl-propionyloxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 220554-70-1 (2E,5S,6R,7E)-5-hydroxy-6-methyl-8-phenylocta-2,7-dienoic acid methyl ester 
• 642087-12-5 (E)-(3S,4R)-3-Hydroxy-4-methyl-6-phenyl-hex-5-enal 
• 329689-44-3 exo-syn-syn-dicarbonyl(η(5)-cyclopentadienyl)-[(1,2,3-η)-(1R,2S,3S)-1-phenylbut-2-en-1-yl]molybdenum(II) 
• 912480-83-2 (R,E)-dimethyl(phenyl)(1-phenyl-1-penten-3-yl)silane 
• 27911-12-2 pent-2-en-1-ylbenzene 
• 81176-43-4 (S)-trans-4-phenyl-3-buten-2-ol 

Relevant academic research and scientific papers

The nucleophilic addition of α-metallated 1,3-dioxanes to planar chiral cationic η3-allylmolybdenum complexes. Synthesis of (2E,5S,6R,7E)-6-methyl-8-phenylocta-2,7-dienoic acid methyl ester, a key component of the Cryptophycins

Two adjacent stereogenic centres and a pendant alkene were constructed via nucleophilic addition of a 1,3-dioxan-4-ylcopper(I) reagent to a cationic η3-allylmolybdenum complex as part of a synthesis of (2E,5S,6R,7E)-6-methyl-8-phenylocta-2,7-di

A synthesis of cryptophycin 4 using a planar chiral molybdenum cationic complex

A synthesis of cytotoxic agent Cryptophycin 4 features a new approach to (5S,6R)-5-hydroxy-6-methyl-8-phenyl-(2E,7E)-dienoic acid in which the anti stereochemistry between two stereogenic centres is secured by addition of a 1,3-dioxan-4-ylcopper(I) reagen

Enantioselective esterifications of unsaturated alcohols mediated by a lipase prepared from Pseudomonas sp.

Competition experiments and measurements of enantioselectivities were used to develop a simple active-site model (Figure 1) for resolutions of β-hydroxy-α-methylene carbonyl compounds III via acyl transfers mediated by lipase from Pseudomonas sp. (AK). Further experiments were used to test and refine this model with respect to resolutions of allylic, propargylic, homopropargylic, and other alcohols (Tables I-IV, respectively). The model proved extremely reliable for predicting the sense of the asymmetric induction, and the combined data collected in this paper give an indication of what structural features of the substrates can be correlated with high enantioselectivities in these resolutions. Furthermore, the results account for the conspicuous reversal of enantioselectivity previously observed in resolutions of γ-hydroxy-α,β-unsaturated esters 35. Kinetic resolutions of two substrates (allenol 14 and dienol 9) via asymmetric epoxidations were performed for comparison with the methodology presented in this paper.