162471-92-3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 162471-58-1 3-<3-(2-tetrahydropyranyloxy)propyl>benzyl alcohol 
• 110-87-2 3,4-dihydro-2H-pyran 
• 162471-57-0 3-[3-(Tetrahydro-pyran-2-yloxy)-propyl]-benzoic acid methyl ester 
• 65537-54-4 3-(3-bromophenyl)-propan-1-ol 
• 162471-59-2 3-<3-(2-tetrahydropyranyloxy)propyl>benzaldehyde 
• 85431-06-7 methyl 3-(3-hydroxypropyl)benzoate 

Downstream Products

• 162471-93-4 3-<3-(2-tetrahydropyranyloxy)propyl>benzyl bromide 
• 162471-96-7 methyl 3-<3-(3-hydroxypropyl)benzyl>phenylacetate 
• 1027524-26-0 {3-[3-(3-Oxo-propyl)-benzyl]-phenyl}-acetic acid methyl ester 
• 162471-95-6 methyl 3-<3-(3-hydroxypropyl)benzyloxy>benzoate 
• 1026818-35-8 3-[3-(3-Oxo-propyl)-benzyloxy]-benzoic acid methyl ester 
• 1026707-56-1 (3-{3-[3-(Tetrahydro-pyran-2-yloxy)-propyl]-benzyl}-phenyl)-acetic acid methyl ester 
• 162471-94-5 3-{3-[3-(Tetrahydro-pyran-2-yloxy)-propyl]-benzyloxy}-benzoic acid methyl ester 
• 1026449-34-2 3-Hydroxy-2-hydroxymethyl-5-[3-(3-methoxycarbonylmethyl-benzyl)-phenyl]-pentanoic acid benzyl ester 
• 1027443-19-1 3-[3-(4-Benzyloxycarbonyl-3,5-dihydroxy-pentyl)-benzyloxy]-benzoic acid methyl ester 

Relevant academic research and scientific papers

ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS

The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 3-Oxetanones with a side chain mimicking the extended structure of 1233A

Structural analogs of 1233A, a microbial metabolite inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, were designed and synthesized. The 2-oxetanone moiety was left intact. All analogs prepared were tested for inhibition of HMG-CoA synt