162489-18-1Relevant articles and documents
Catalytic asymmetric intramolecular homologation of ketones with α-diazoesters: Synthesis of cyclic α-Aryl/Alkyl β-ketoesters
Li, Wei,Tan, Fei,Hao, Xiaoyu,Wang, Gang,Tang, Yu,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming
supporting information, p. 1608 - 1611 (2015/01/30)
A catalytic asymmetric intramolecular homologation of simple ketones with α-diazoesters was firstly accomplished with a chiral N,N′-dioxide-Sc(OTf)3 complex. This method provides an efficient access to chiral cyclic α-aryl/alkyl β-ketoesters containing an all-carbon quaternary stereocenter. Under mild conditions, a variety of aryl- and alkyl-substituted ketone groups reacted with α-diazoester groups smoothly through an intramolecular addition/rearrangement process, producing the β-ketoesters in high yield and enantiomeric excess.
Total synthesis of herbertenediol, an isocuparane sesquiterpene isolated from liverworts
Fukuyama, Yoshiyasu,Kiriyama, Yuuko,Kodama, Mitsuaki
, p. 1261 - 1264 (2007/10/03)
Total synthesis of herbertenediol, an isocuparane-sesquiterpene possessing a potent anti-lipid peroxidation activity isolated from a liverwort, has been achieved via herbertenol using intramolecular Heck reaction as the key step.
Asymmetric Alkylation Using Chiral Cyclic Diols to Prepare a Quaternary Carbon
Kato, Keisuke,Suemune, Hiroshi,Sakai, Kiyoshi
, p. 3315 - 3326 (2007/10/02)
Asymmetric alkylation of cyclic and acyclic β-keto ester acetals (4, 5, 13, 14, and 18) with C2-symmetric cycloalkane-1,2-dioxy moiety proceeded in a highly diastereoselective manner to afford enol ethers (9-12, 15-17, 19a-c) with a chiral quat