16251-32-4Relevant academic research and scientific papers
Preparation method of 3-aryl propanol
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, (2017/08/28)
The invention discloses a preparation method of 3-aryl propanol. According to the preparation method, 3-aryl benzaldehyde and acetate are dissolved into an organic solvent, a catalyst is added at a certain temperature to carry out condensation reactions to prepare 3-aryl-2-alkene ester, then 3-aryl-2-alkene ester and a reducing agent carry out reduction reactions to obtain the final product 3-aryl propanol. The provided method adopts aryloxy to replace benzaldehyde to carry out condensation reactions with acetate, and then the reaction product is reduced to prepare 3-aryl propanol. Aromatic aldehyde and acetate carry out condensation reactions in the presence of a catalyst to prepare a Knoevenagel like condensate namely 3-aryl-2-alkene ester, and then 3-aryl-2-alkene ester is reduced by a reducing agent to prepare aryl propanol. The total yield is greater than 80%. The content is more than 95%. The raw materials are cheap, and the sources are wide. The preparation method is safer and more convenient. Moreover, the production cost is low, the raw materials is nontoxic or little toxic, the total yield is high, the generated waste gas, waste water, and waste solid are little, and the industrialization is easy.
PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS
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Paragraph 0125, (2016/12/01)
The present invention relates to novel compounds which are highly selective inhibitors of diacylglycerol lipase α and β. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by increased 2-arachidonoylglycerol levels. Diacylglycerol lipase-α (alternative name: Sn1-specific diacylglycerol hydrolase a; DAGL-α) and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion. The inventive ompounds are in particular suitable for the treatment of neurodegenerative diseases, inflammatory diseases, drug abuse and impaired energy balance, such as obesity.
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in staphylococcus aureus
Song, Yongcheng,Lin, Fu-Yang,Yin, Fenglin,Hensler, Mary,Poveda, Carlos A. Rodrígues,Mukkamala, Dushyant,Cao, Rong,Wang, Hong,Morita, Craig T.,Pacanowska, Dolores González,Nizet, Victor,Oldfield, Eric
experimental part, p. 976 - 988 (2009/12/04)
Staphylococcus aureus produces a golden carotenoid virulence factor called staphyloxanthin (STX), and we report here the inhibition of the enzyme, dehydrosqualene synthase (CrtM), responsible for the first committed step in STX biosynthesis. The most acti
Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues
Burlingame, Mark A.,Shaw, Simon J.,Sundermann, Kurt F.,Zhang, Dan,Petryka, Joseph,Mendoza, Esteban,Liu, Fenghua,Myles, David C.,LaMarche, Matthew J.,Hirose, Tomoyasu,Freeze, B. Scott,Smith III, Amos B.
, p. 2335 - 2338 (2007/10/03)
A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for cytotoxicity.
