2509-20-8Relevant academic research and scientific papers
Preparation method of 3-aryl propanol
-
Paragraph 0032; 0033, (2017/08/28)
The invention discloses a preparation method of 3-aryl propanol. According to the preparation method, 3-aryl benzaldehyde and acetate are dissolved into an organic solvent, a catalyst is added at a certain temperature to carry out condensation reactions to prepare 3-aryl-2-alkene ester, then 3-aryl-2-alkene ester and a reducing agent carry out reduction reactions to obtain the final product 3-aryl propanol. The provided method adopts aryloxy to replace benzaldehyde to carry out condensation reactions with acetate, and then the reaction product is reduced to prepare 3-aryl propanol. Aromatic aldehyde and acetate carry out condensation reactions in the presence of a catalyst to prepare a Knoevenagel like condensate namely 3-aryl-2-alkene ester, and then 3-aryl-2-alkene ester is reduced by a reducing agent to prepare aryl propanol. The total yield is greater than 80%. The content is more than 95%. The raw materials are cheap, and the sources are wide. The preparation method is safer and more convenient. Moreover, the production cost is low, the raw materials is nontoxic or little toxic, the total yield is high, the generated waste gas, waste water, and waste solid are little, and the industrialization is easy.
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in staphylococcus aureus
Song, Yongcheng,Lin, Fu-Yang,Yin, Fenglin,Hensler, Mary,Poveda, Carlos A. Rodrígues,Mukkamala, Dushyant,Cao, Rong,Wang, Hong,Morita, Craig T.,Pacanowska, Dolores González,Nizet, Victor,Oldfield, Eric
experimental part, p. 976 - 988 (2009/12/04)
Staphylococcus aureus produces a golden carotenoid virulence factor called staphyloxanthin (STX), and we report here the inhibition of the enzyme, dehydrosqualene synthase (CrtM), responsible for the first committed step in STX biosynthesis. The most acti
Practical one-pot syntheses of ethyl 4-substituted-1 H-pyrrole-3- carboxylates from aldehydes
Chang, Jay Hyok,Shin, Hyunik
, p. 291 - 293 (2013/01/03)
Ethyl 4-substituted-1H-pyrrole-3-carboxylates were prepared in a one-pot manner starting from aromatic or aliphatic aldehydes via a Horner-Wadsworth- Emmons reaction and subsequent reaction with tosylmethylisocyanide (TosMIC) in the presence of sodium tert-amylate in toluene. Judicious selection of base and solvent led to the use of a single solvent, i.e., toluene, for reactions as well as for crystallization to render the one-pot process more practical and greener than the stepwise version. hisin@ lels.com.
