16251-41-5

Basic information

• Product Name: 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline
• CAS NO: 16251-41-5
• Molecular Formula: C₂₀H₂₂N₂O₆
• Molecular Weight: 386.3985
• Mol File: 16251-41-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 556.3°C at 760 mmHg
• Flash Point: 290.2°C
• Density: 1.28g/cm³
• Vapor Pressure: 7.67E-12mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline(16251-41-5)
• EPA Substance Registry System: 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline(16251-41-5)

Safety Data

• Hazardous Substances Data: 16251-41-5(Hazardous Substances Data)

Usage

General Description

1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline, also known as Ro 5-4864, is a chemical compound with potential pharmacological effects. It belongs to the class of isoquinoline derivatives and is a ligand for the peripheral-type benzodiazepine receptor (PBR). 1-(4,5-dimethoxy-2-nitrobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline has been studied for its potential use in the treatment of anxiety, depression, and neurodegenerative diseases. It has also been investigated for its role in modulating the production of inflammatory cytokines and for its potential anti-inflammatory properties. Further research is needed to fully understand the pharmacological effects and potential therapeutic applications of this compound.

Upstream product

• 4230-93-7 3,4-dimethoxynitrostyrene 
• 53602-52-1 4,5-dimethoxy-2-nitrophenylacetic acid chloride 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 73357-18-3 (4,5-dimethoxy-2-nitrophenyl)acetic acid 
• 2129-52-4 N-(3,4-dimethoxyphenethyl)-2-(4,5-dimethoxy-2-nitrophenyl)-acetamide 

Downstream Products

• 20323-72-2 (6,7-dimethoxyisoquinolin-1-yl)(4,5-dimethoxy-2-nitrophenyl)-methanone 
• 5574-24-3 oxoglaucine 
• 83511-44-8 1-(2'-amino-4',5'-dimethoxy-α-oxobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 77538-74-0 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline methiodide 
• 77513-48-5 1-(4',5'-dimethoxy-2'-nitro-α-oxobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline 

Relevant articles and documents

Novel total syntheses of oxoaporphine alkaloids enabled by mild Cu-catalyzed tandem oxidation/aromatization of 1-Bn-DHIQs

Novel total syntheses of oxoaporphine alkaloids such as liriodenine, dicentrinone, cassameridine, lysicamine, oxoglaucine and O-methylmoschatoline were developed. The key step of these total syntheses is Cu-catalyzed conversion of 1-benzyl-3,4-dihydro-isoquinolines (1-Bn-DHIQs) to 1-benzoyl-isoquinolines (1-Bz-IQs) via tandem oxidation/aromatization. This novel Cu-catalyzed conversion has been studied in detail, and was successfully used for constructing the 1-Bz-IQ core.

The SYNTHESIS OF ERYTHRO- AND THREO-N-METHYL 7-HYDROXY-1,2,9,10-TETRAMETHOXYAPORPHINE

The total synthesis of the title compounds is described.