162544-53-8Relevant academic research and scientific papers
Enantioselective Michael additions of nitromethane by a catalytic double activation method using chiral Lewis acid and achiral amine catalysts
Itoh, Kennosuke,Kanemasa, Shuji
, p. 13394 - 13395 (2002)
Reactions of nitromethane with 1-(2-alkenoyl)-3,5-dimethylpyrazoles can be effectively catalyzed by R,R-DBFOX/Ph·Ni(ClO4)2·3H2O and achiral amine bases, each in a catalytic loading of 10 mol %, to give 1-(3-substituted 4-n
Synthesis of the novel antidepressant (R)-(-)-Rolipram
Langlois, Nicole,Wang, Hai-Shan
, p. 3133 - 3144 (2007/10/03)
Enantioselective synthesis of (R)-Rolipram 1 has been achieved through a conjugate addition of cyanide to enantiomerically pure 2-(2-aryl ethenyl)oxazoline 2, followed by selective reduction of the adduct with NaBH4-NiCl2.
