162559-02-6Relevant articles and documents
Synthesis of Plakortolides e and i Enabled by Base Metal Catalysis
Leisering, Stefan,Mavroskoufis, Alexandros,Vo?nacker, Patrick,Zimmer, Reinhold,Christmann, Mathias
, p. 4731 - 4735 (2021)
A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key steps are a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines chemoselective bond-forming reactions and one-pot operations to forge an overall efficient synthesis.