Welcome to LookChem.com Sign In|Join Free

CAS

  • or

16264-05-4

Post Buying Request

16264-05-4 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

16264-05-4 Usage

General Description

1,4-bis(4-nitrophenyl)piperazine is a chemical compound that consists of two 4-nitrophenyl groups attached to a piperazine backbone. It is commonly used as a building block in the synthesis of organic compounds and pharmaceutical drugs. 1,4-bis(4-nitrophenyl)piperazine has been studied for its potential as an anti-cancer agent, as well as for its ability to inhibit certain enzymes in the body. It is also used in the production of dyes and pigments. However, 1,4-bis(4-nitrophenyl)piperazine is considered to be hazardous to human health and the environment, and proper safety measures should be followed when handling and working with this chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 16264-05-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,6 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 16264-05:
(7*1)+(6*6)+(5*2)+(4*6)+(3*4)+(2*0)+(1*5)=94
94 % 10 = 4
So 16264-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H16N4O4/c21-19(22)15-5-1-13(2-6-15)17-9-11-18(12-10-17)14-3-7-16(8-4-14)20(23)24/h1-8H,9-12H2

16264-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4-bis(4-nitrophenyl)piperazine

1.2 Other means of identification

Product number -
Other names 1,4-Di-p-nitrophenyl-piperazin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16264-05-4 SDS

16264-05-4Relevant articles and documents

Preparation method of posaconazole intermediate

-

Paragraph 0029-0032, (2021/04/21)

The invention discloses a preparation method of a posaconazole intermediate shown as a formula I. According to the method, p-brominated nitrobenzene and anhydrous piperazine are used as raw materials, and a target product is prepared through a condensation reaction, a reduction reaction, a monoacylation reaction, a cyclization reaction and a diazotization hydrolysis reaction. Compared with a synthesis method taking 1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine as a starting material in the prior art, the preparation method provided by the invention has the advantages that the raw materials are easy to obtain, the reaction efficiency is high, the reaction conditions are mild, the yield of a target product is high, the operation is simple and convenient, the efficiency is high, and the cost is low.

1,4-Diarylpiperazines and analogs as anti-tubercular agents: Synthesis and biological evaluation

Forge,Cappoen,Laurent,Stanicki,Mayence,Huang,Verschaeve,Huygen,Vanden Eynde

scheme or table, p. 95 - 101 (2012/04/10)

Despite progress in modern chemotherapy to combat tuberculosis, the causative pathogen Mycobacterium tuberculosis (M.tb.) is far from eradicated. Bacillary resistance to anti-mycobacterial agents, bacillary persistence and human immunodeficiency virus (HIV) co-infection hamper current drug treatment to completely cure the infection, generating a constant demand for novel drug candidates to tackle these problems. A small library of novel heterocyclic compounds was screened in a rapid luminometric in vitro assay against the laboratory M.tb. strain H37Rv. A group of amidines was found to have the highest potency and was further evaluated for acute toxicity against C3A hepatocytes. Next, the most promising compounds were evaluated for activity against a multi-drug resistant clinical isolate. The group of amidines was also tested for their ability to kill intracellular M.tb. residing in mouse J774A.1 macrophages. Finally, we report on a correlation between the structural differences of the compounds and their anti-mycobacterial activity.

Synthesis, antituberculosis activity, and DNA binding affinity of a highly diverse library of 1,4-diarylpiperazines

Vanden Eynde, Jean Jacques,Mayence, Annie,Lecour Jr., Louis,Huang, Tien L.

, p. 401 - 414 (2007/10/03)

A library of eighteen 1,4-diarylpiperazines has been synthesized and evaluated for antituberculosis activity and DNA binding affinity. Among them, 4,4′-(1,4-piperazinediyl)bis(N-alkylbenzenecarboximidamides) emerged as attractive leads for further drug development.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 16264-05-4