162691-86-3Relevant academic research and scientific papers
Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety
Ghorab, Moustafa M.,Barakat, Saber El-Sayed,Saker, Helmy M.,Abd Rabo, Mahmoud M.
, p. 665 - 670 (2008/02/12)
The reactivity of isothiocyanate 1 towards some nitrogen nucleophils was investigated. Thus, interaction of 1 with p-flouroaniline, benzylamine, 2-aminopyridine, and 4-aminoantipyrine yielded the corresponding quinazoline derivatives 37, respectively. Tri
Synthesis and reactions of some 3-aryl-2-thioxoquinazolin-4(3H)-ones
El-Hiti, Gamal A.,Abdel-Megeed, Mohamed F.,Zied, Tarek M. M.
, p. 1519 - 1522 (2007/10/03)
A series of 3-aryl-2-thioxoquinazolin-4(3H)-ones la-g are prepared in good yields from reactions of anthranilic acids, aromatic amines and carbon disulfide under basic conditions in one step. Reaction of aminophenyl derivatives la,b with D-glucose affords the corresponding N-glucosylamines 4a,b in very good yields. Diazotization of la,b followed by reactions with aromatic amines yield the corresponding azo dyes 6a-f in 40-56% yields. The fastness for 6 has been studied. Compounds 6a,b,f have been proved to biologically active.
