162693-64-3Relevant academic research and scientific papers
Synthesis and antiviral evaluation of some 5-N-arylaminomethyl-2- glycosylsulphanyl-1,3,4-oxadiazoles and their analogs against hepatitis A and herpes simplex viruses
El-Sayed, Wael A.,Fathi, Nahed M.,Gad,El-Ashry, El Sayed H.
, p. 357 - 372 (2008/12/23)
N-Arylaminomethyl-3H-1,3,4-oxadiazole-2-thiones 2a,b were prepared from the corresponding N-arylglycinoylhydrazides. A number of their thioglycoside derivatives 4-7a-c and S-functionalized analogs 8-11a,b were synthesized by the reaction with different acetobromosugars and acyclic hydroxyalkylating agents. The antiviral activity of a number of the synthesized compounds against herpes simplex virus type 1 (HSV-1) and hepatitis A virus (HAV) was evaluated. Compounds 5a and 5b showed promising results against HAV. Copyright Taylor & Francis Group, LLC.
