162706-25-4Relevant academic research and scientific papers
Nickel-Catalyzed system for the cross-coupling of alkenyl methyl ethers with grignard reagents under mild conditions
Hostier, Thomas,Neouchy, Zeina,Ferey, Vincent,Gomez Pardo, Domingo,Cossy, Janine
supporting information, p. 1815 - 1818 (2018/04/14)
A nickel-catalyzed cross-coupling of alkenyl methyl ethers with Grignard reagents, under mild conditions, is described. These conditions allowed access to various stilbenes and heterocyclic stilbenic derivatives as well as to a potential anticancer agent DMU-212.
Reductive N-Arylethylation of Aromatic Amines and N-Heterocycles with Enol Ethers
V?gerl, Katharina,Ong, Duc Nghia,Bracher, Franz
, p. 1323 - 1330 (2017/12/26)
A convenient method for N-arylethylation of aromatic amines and heterocycles under mild reductive conditions was developed using (2-methoxyvinyl)(hetero)arenes as building blocks and triethylsilane/trifluoroacetic acid as reducing agent. This protocol is compatible with numerous functional groups, and aliphatic amines are inert due to protonation.
Enol ethers as carbonyl surrogates in a modification of the Povarov synthesis of 3-aryl quinolines and their anti-Toxoplasma activity
Brown, Carla E.,McNulty, James,Bordón, Claudia,Yolken, Robert,Jones-Brando, Lorraine
supporting information, p. 5951 - 5955 (2016/07/06)
A novel method for the preparation of 2-carboxyl-3-aryl quinoline derivatives from anilines, ethyl glyoxalate and enol ethers as phenylacetaldehyde surrogates is reported. The three-component coupling reaction occurs rapidly under mild conditions in dichl
Intermolecular Hydroalkoxylation of Terminal Alkynes Catalyzed by a Dipyrrinato Rhodium(I) Complex with Unusual Selectivity
Lam, Raphael H.,Walker, D. Barney,Tucker, Matthew H.,Gatus, Mark R. D.,Bhadbhade, Mohan,Messerle, Barbara A.
supporting information, p. 4312 - 4317 (2015/09/22)
An operationally simple and atom-economical method for the E-selective preparation of enol ethers is described. A novel dicarbonyl(5-phenyldipyrrinato)rhodium complex, 2, was prepared in four synthetic steps, characterized by X-ray crystallography and NMR
Microwave-assisted in situ deprotection and ω-methoxylation of TMS-protected aryl alkynes
Wettergren, Jenny,Minidis, Alexander B. E.
, p. 7611 - 7612 (2007/10/03)
Using microwave technology, rapid ω-methoxylation of aryl alkynes is possible.
Novel Compounds
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, (2008/06/13)
The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.
Indole derivatives thromboxane A2 antagonists
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, (2008/06/13)
Compounds of formula (I): STR1 and pharmaceutically acceptable salt and biolabile esters thereof, wherein R1 is H, C1 -C4 alkyl, phenyl optionally substituted by up to three substituents independently selected from C1 -C4 alkyl, C1 -C4 alkoxy, halogen and CF3, or is 1-imidazolyl, 3-pyridyl or 4-pyridyl; R2 is H or C1 -C4 alkyl, R3 is SO2 R4 or COR4 where R4 is C1 -C6 alkyl, C1 -C3 perfluoroalkyl(CH2)p, C3 -C6 cycloalkyl(CH2)p, aryl(CH2)p, or heteroaryl(CH2)p, p being 0, 1 or 2, or R4 may be NR5 R6 where R5 is H or C1 -C4 alkyl and R6 is C1 -C6, alkyl, C3 -C6 cycloalkyl or aryl, or R5 and R6 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring which may optionally incorporate a carbon-carbon double bond or a further heteroatom linkage selected from O, S, NH, N(C1 -C4 alkyl) and N(C1 -C5 alkanoyl); X is CH2 or a direct link, with the proviso that when R1 is 1-imidazolyl then X is CH2 ; m is 2, or 3; n is 0, 1 or 2, and wherein the group (CH2)n NHR3 is attached at the 5-position when n is 0 or 1, or at the 5- or 4-position when n is 2. These compounds are selective TXA2 and PGH2 antagonists. Some also inhibit thromboxane synthetase.
