162708-85-2Relevant academic research and scientific papers
Synthesis of a Highly Functionalised AB Taxane Ring System: Formation of the Eight-membered Ring by an Efficient 8-exo-tet Alkylation of an α-Sulfonyl Anion
Crich, David,Natarajan, Swaminathan
, p. 85 - 86 (1995)
An efficient, scalable route to a Taxol A ring synthon has been developed; its successful elaboration to a highly functionalized AB system by means of a novel nucleophilic ring closure is described.
Synthesis of the taxol AB-system by olefination of an A-ring C1 ketone and direct B-ring closure
Crich, David,Natarajan, Swaminathan,Crich, Joyce Z.
, p. 7139 - 7158 (2007/10/03)
Two syntheses of 13-deoxy-taxol C1 ketones are presented. Olefination of these C1 ketones is achieved, indirectly, via either the Meyer-Schuster reaction or by introduction of a vinyl group with vinylcerium dichloride followed by allylic rearrangement. Bo
