1627210-18-7

Basic information

• Product Name: C₁₇H₁₂BrNO₂
• Synonyms: C₁₇H₁₂BrNO₂
• CAS NO: 1627210-18-7
• Molecular Weight: 342.192
• Mol File: 1627210-18-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₂BrNO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₂BrNO₂(1627210-18-7)
• EPA Substance Registry System: C₁₇H₁₂BrNO₂(1627210-18-7)

Safety Data

• Hazardous Substances Data: 1627210-18-7(Hazardous Substances Data)

Upstream product

• 884855-67-8 4-bromo-1-methylindoline-2,3-dione 
• 98-86-2 acetophenone 
• 20780-72-7 4-bromoisatin 

Relevant articles and documents

Isocyanide-based multicomponent reactions: Concise synthesis of spirocyclic oxindoles with molecular complexity by using a [1,5]-hydrogen shift as the key step

A concise multicomponent reaction of isocyanide, α-substituted allenoate, and methyleneindolinone has been disclosed. This protocol provides a fast and straightforward approach to synthesize unusual tricyclic oxindoles in an efficient and atom-economic manner. Mechanistically, the present cycloaddition may proceed through a cascade sequence involving double Michael addition, double cyclization, double [1,5]-hydrogen shift, and group migration. The introduction of a special alkyl group to the allenoate is believed to play a key role in the cascade reaction. This method also features a broad substrate scope, which is particularly useful for the delivery of a large number of compounds. Shift your perspective! An unprecedented cascade reaction, under mild conditions, involving a double Michael addition, double cyclization, and double [1,5]-hydrogen shift, followed by group migration is disclosed. This reaction offers a fast and straightforward approach to unusual polycyclic spirooxindoles (see scheme).