162739-75-5Relevant academic research and scientific papers
Towards a general synthesis of di-aza-amino acids containing peptides
Bizet, Faustine,Tonali, Nicolo,Soulier, Jean-Louis,Oliva, Agostino,Kaffy, Julia,Crousse, Benoit,Ongeri, Sandrine
, p. 17062 - 17072 (2018)
While the incorporation of one aza-amino acid in peptides has been proved to be beneficial for inducing a structure constraint, increasing the resistance towards proteolysis and improving the biological activity, only very rare examples of the incorporation of two or more consecutive aza-amino acids have been reported. In this work, we demonstrate that this fact is probably due to the unsuspected difficulty in synthesizing such peptide analogues, as illustrated by the synthesis of tripeptide derivatives containing two consecutive aza-amino acids. Herein, we report some general guidelines regarding the activation and the coupling of alkyl-hydrazides either mutually or with a natural amino acid, taking into account their nucleophilicity and the nature of their side chains.
RETROVIRAL PROTEASE INHIBITING COMPOUNDS
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, (2008/06/13)
A retroviral protease inhibiting compound of the formula: STR1 is disclosed wherein R 1, R 2, R 5, R 6, Y m and Y' n are herein defined.
