1627941-97-2

Basic information

• Product Name: 3-O-{2-cyanoethyl(diisopropylamino)phosphino}-5'-O-(4,4'-dimethoxytrityl)-5-(4-phenyldiazenylphenyl)ethynyl-2'-deoxyuridine
• CAS NO: 1627941-97-2
• Molecular Weight: 935.029
• Mol File: 1627941-97-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-O-{2-cyanoethyl(diisopropylamino)phosphino}-5'-O-(4,4'-dimethoxytrityl)-5-(4-phenyldiazenylphenyl)ethynyl-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-{2-cyanoethyl(diisopropylamino)phosphino}-5'-O-(4,4'-dimethoxytrityl)-5-(4-phenyldiazenylphenyl)ethynyl-2'-deoxyuridine(1627941-97-2)
• EPA Substance Registry System: 3-O-{2-cyanoethyl(diisopropylamino)phosphino}-5'-O-(4,4'-dimethoxytrityl)-5-(4-phenyldiazenylphenyl)ethynyl-2'-deoxyuridine(1627941-97-2)

Safety Data

• Hazardous Substances Data: 1627941-97-2(Hazardous Substances Data)

Upstream product

• 1009039-99-9 (E)-1-phenyl-2-[4-(ethynyl)phenyl]diazene 
• 54-42-2 5-Iodo-2'-deoxyuridine 
• 1627941-94-9 5'-O-(4,4'-dimethoxytrityl)-5-(4-phenyldiazenylphenyl)ethynyl-2'-deoxyuridine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 

Relevant articles and documents

C5-azobenzene-substituted 2'-deoxyuridine-containing oligodeoxynucleotides for photo-switching hybridization

A new photoisomeric nucleoside dUAz bearing an azobenzene group at the C5-position of 2'-deoxyuridine was designed and synthesized. Photoisomerization of dUAz in oligodeoxynucleotides can be achieved rapidly and selectively with 365 nm (forward) and 450 nm (backward) irradiation. Thermal denaturation experiments revealed that dUAz stabilized the duplex in the cis-form and destabilized it in the trans-form with mismatch discrimination ability comparable to thymidine. These results indicate that dUAz could be a powerful material for reversibly manipulating nucleic acid hybridization with spatiotemporal control.