162809-92-9Relevant academic research and scientific papers
The chemistry of the taxane diterpene: Stereoselective reductions of taxanes
Georg, Gunda I.,Harriman, Geraldine C. B.,Datta, Apurba,Ali, Syed,Cheruvallath, Zacharia,Dutta, Dinah,Vander Velde, David G.,Himes, Richard H.
, p. 8926 - 8934 (2007/10/03)
Stereoselective reductions of taxanes are detailed. Chelation- controlled reductions employing SmI2 are described for the stereoselective reduction of the 9-keto functionality of the diterpene moiety of several taxanes. In all cases the 9β-hydr
Syntheses of Novel C-9 and C-10 Modified Bioactive Taxanes
Datta, Apurba,Velde, David G. Vander,Georg, Gunda I.
, p. 1985 - 1988 (2007/10/02)
A method has been developed for the syntheses of hitherto unreported C-9 and C-10 modified taxanes.These analogs demonstrated excellent to good cytotoxicity against B 16 melanoma cells.
